PMID- 20413858
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220316
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 20
IP  - 3
DP  - 2010
TI  - Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease.
PG  - 711-22
LID - 10.3233/JAD-2010-100012 [doi]
AB  - The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the 
      importance of finding effective preventive therapies for this devastating 
      disease. Midlife vascular risk factors, including type 2 diabetes mellitus 
      (T2DM), have been associated with increased risk of AD decades later and may 
      serve as targets for AD prevention. Studies to date suggest that T2DM and 
      hyperinsulinemia increase risk for AD, possibly through their effects on 
      amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in 
      preclinical AD pathology. This paper reviews the evidence supporting a 
      relationship between T2DM, hyperinsulinemia, and diabetic dyslipidemia on the 
      development of AD, discusses DM treatment trials and their preliminary results on 
      cognitive function, and proposes some strategies for optimizing future AD 
      prevention trial design.
FAU - Carlsson, Cynthia M
AU  - Carlsson CM
AD  - Department of Medicine, Section of Geriatrics and Gerontology, University of 
      Wisconsin School of Medicine and Public Health, William S. Middleton Memorial 
      Veterans Hospital Geriatric Research, Education and Clinical Center (GRECC), 
      Wisconsin Alzheimer's Disease Research Center, Madison, WI 53705, USA. 
      cmc@medicine.wisc.edu
LA  - eng
GR  - K23 AG026752/AG/NIA NIH HHS/United States
GR  - P50 AG033514/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Alzheimer Disease/*complications/prevention & control
MH  - Animals
MH  - Diabetes Complications/*complications
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Dyslipidemias/*complications
MH  - Humans
MH  - Risk Factors
PMC - PMC4235787
MID - NIHMS484645
COIS- The author has no conflicts of interest to disclose.
EDAT- 2010/04/24 06:00
MHDA- 2010/09/09 06:00
PMCR- 2014/11/18
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
PHST- 2014/11/18 00:00 [pmc-release]
AID - D145H1Q081023W1M [pii]
AID - 10.3233/JAD-2010-100012 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2010;20(3):711-22. doi: 10.3233/JAD-2010-100012.