PMID- 20414542
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20190917
IS  - 1677-9487 (Electronic)
IS  - 0004-2730 (Linking)
VI  - 54
IP  - 1
DP  - 2010 Feb
TI  - [Environmental contaminants and endocrine disruptors].
PG  - 6-16
LID - S0004-27302010000100003 [pii]
AB  - The toxicity of various pollutants has been routinely investigated according to 
      their teratogenic and carcinogenic effects. In the last few decades, however, 
      many of such pollutants have been shown to adversely affect the endocrine system 
      of human beings and other species. Currently, more than eleven million chemical 
      substances are known in the world, and approximately 3,000 are produced on a 
      large scale. Numerous chemical composites of domestic, industrial and 
      agricultural use have been shown to influence hormonal activity. Examples of such 
      chemical products with estrogenic activity are substances used in cosmetics, 
      anabolizing substances for animal feeding, phytoestrogens and persistent organic 
      pollutants (POPs). These agents are seen in residential, industrial and urban 
      sewerage system effluents and represent an important source of environmental 
      contamination. The International Programme on Chemical Safety (IPCS) defines as 
      endocrine disruptors substances or mixtures seen in the environment capable of 
      interfering with endocrine system functions resulting in adverse effects in an 
      intact organism or its offspring. In this article the authors present a current 
      literature review about the role of these pollutants in endocrine and metabolic 
      diseases, probable mechanisms of action, and suggest paths of investigation and 
      possible strategies for prevention and reduction of its possible damages.
FAU - Fontenele, Eveline Gadelha Pereira
AU  - Fontenele EG
AD  - Servico de Endocrinologia e Diabetes, Hospital Universitario Walter Cantidio, 
      Universidade Federal do Ceara, Fortaleza, CE, Brasil. eveline@huwc.ufc.br
FAU - Martins, Manoel Ricardo Alves
AU  - Martins MR
FAU - Quidute, Ana Rosa Pinto
AU  - Quidute AR
FAU - Montenegro, Renan Magalhaes Jr
AU  - Montenegro RM Jr
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Contaminantes ambientais e os interferentes endocrinos.
PL  - Brazil
TA  - Arq Bras Endocrinol Metabol
JT  - Arquivos brasileiros de endocrinologia e metabologia
JID - 0403437
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Endocrine Disruptors/classification/*toxicity
MH  - Environmental Exposure/*prevention & control
MH  - Environmental Pollutants/classification/*toxicity
MH  - Humans
EDAT- 2010/04/24 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/07/05 00:00 [received]
PHST- 2009/11/22 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S0004-27302010000100003 [pii]
AID - 10.1590/s0004-27302010000100003 [doi]
PST - ppublish
SO  - Arq Bras Endocrinol Metabol. 2010 Feb;54(1):6-16. doi: 
      10.1590/s0004-27302010000100003.