PMID- 20416191
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Apr
TI  - [A case of myelodysplastic syndrome with aberrant evolution of chromosome 1 and 
      11 in 6 years of follow-up].
PG  - 469-72
AB  - This study was aimed to investigate the relationship between cytogenetic 
      evolution and disease progression in patient with MDS-RAEB. By a long term (6 
      years) follow-up of a patient with MDS-RAEB, peripheral blood cell count, bone 
      marrow cell morphology and conventional cytogenetics were monitored regularly. In 
      addition, fluorescence in situ hybridization (FISH) was applied to confirm the 
      aberrant karyotype. The results indicated that this patient was failed with 
      conventional chemotherapy of AML, but had response to ATRA and 6-MP in the 72 
      months follow-up. At initial diagnosis, the cytogenetics analysis showed normal 
      karyotype, whereas 46, XY, 2q+[1]/46, XY[19] was found at 48 months, 46, XY, 
      dup(1q)[3]/46, XY[7] at 56 months, and dup (1) as well as der (11) with complex 
      karyotype at 68 months, which was accompanied by progressive decrease of platelet 
      count. It is concluded that karyotype evolution is perhaps associated with 
      progression of MDS.
FAU - Lu, Xin
AU  - Lu X
AD  - Department of Hematology, Jiangsu Province Hospital, the First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
FAU - Qiu, Hong-Xia
AU  - Qiu HX
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Zhang, Su-Jiang
AU  - Zhang SJ
FAU - Xu, Ji
AU  - Xu J
FAU - Xu, Wei
AU  - Xu W
FAU - Wu, Han-Xin
AU  - Wu HX
FAU - Li, Jian-Yong
AU  - Li JY
FAU - Shao, Jing-Zhang
AU  - Shao JZ
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 11
MH  - Follow-Up Studies
MH  - Humans
MH  - *Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 2010/04/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 1009-2137(2010)02-0469-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr;18(2):469-72.