PMID- 20416358
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20121115
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 477
IP  - 1
DP  - 2010 Jun 14
TI  - Fructose-1,6-diphosphate inhibits seizure acquisition in fast hippocampal 
      kindling.
PG  - 33-6
LID - 10.1016/j.neulet.2010.04.030 [doi]
AB  - Inhibition of glycolytic metabolism may provide a new therapy for refractory 
      epilepsy. Fructose-1,6-diphosphate (FDP), which inhibits glycolysis and diverts 
      glucose into the pentose phosphate pathway, has strong inhibitory action on 
      seizures induced by chemical convulsants. Here, we investigated the effect of FDP 
      on a rat model of rapid hippocampal kindling. After determining the 
      after-discharge threshold (ADT), the seizure severity and after-discharge 
      duration (ADD) were measured to study the antiepileptogenic effects of FDP (0.5 
      or 1.0 g/kg i.p. for 4 days). The mRNA expression levels of the brain-derived 
      neurotrophic factor (BDNF) and its principal receptor TrkB, which are key 
      modulators of seizure activity, were determined in the ipsilateral hippocampus by 
      real-time polymerase chain reaction (RT-PCR). High-dose FDP (1.0 g/kg) delayed 
      kindling development together with shortened ADD, and high-dose treated rats also 
      needed more kindling stimulations and more cumulative ADD to stage 4. However, it 
      showed no significant antiepileptogenic effect at a lower dose of 0.5 g/kg. In 
      addition, FDP attenuated BDNF and TrkB expression before and during kindling 
      procedure; this result indicated that BDNF/TrkB signaling pathway may participate 
      in the antiepileptogenic action of FDP. Our data demonstrates that FDP has a 
      significant antiepileptogenic effect in kindling seizures and that it may be a 
      potential antiepileptic drug in the future.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Ding, Yao
AU  - Ding Y
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, No. 88, Jiefang Road, Hangzhou 310009, China.
FAU - Wang, Shuang
AU  - Wang S
FAU - Zhang, Man-man
AU  - Zhang MM
FAU - Guo, Yi
AU  - Guo Y
FAU - Yang, Yi
AU  - Yang Y
FAU - Weng, Shu-qun
AU  - Weng SQ
FAU - Wu, Ji-min
AU  - Wu JM
FAU - Qiu, Xia
AU  - Qiu X
FAU - Ding, Mei-ping
AU  - Ding MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fructosediphosphates)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - M7522JYX1H (fructose-1,6-diphosphate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/physiology
MH  - Fructosediphosphates/metabolism/*pharmacology
MH  - *Kindling, Neurologic
MH  - Male
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/biosynthesis/physiology
MH  - Seizures/metabolism/*physiopathology
MH  - Signal Transduction
EDAT- 2010/04/27 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/02/17 00:00 [received]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/04/14 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S0304-3940(10)00477-5 [pii]
AID - 10.1016/j.neulet.2010.04.030 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Jun 14;477(1):33-6. doi: 10.1016/j.neulet.2010.04.030. Epub 
      2010 Apr 21.