PMID- 20417687
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20220311
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 477
IP  - 1
DP  - 2010 Jun 14
TI  - Effect of analgesic standards on persistent postoperative pain evoked by 
      skin/muscle incision and retraction (SMIR).
PG  - 43-7
LID - 10.1016/j.neulet.2010.04.033 [doi]
AB  - Various common surgeries such as thoracotomy and inguinal hernia repair involve 
      essential prolonged tissue retraction, often causing persistent postoperative 
      pain. A new model was developed to mimic this clinical scenario, whereby 
      skin/muscle incision and retraction (SMIR) in the medial thigh evoked persistent 
      postoperative pain (Flatters (2008) [Pain 135:119-130]). This study examines the 
      response of SMIR-evoked mechanical hypersensitivity to analgesic standards 
      commonly used as positive controls in behavioural pain studies. Rats were 
      anaesthetised, the skin and superficial muscle of the medial thigh was then 
      incised and retracted for 1h. In separate experiments, morphine, gabapentin and 
      MK-801 were intraperitoneally administered to SMIR-operated rats, at maximally 
      tolerated doses, on postoperative day 9-13. Mechanical hypersensitivity was 
      measured by withdrawal responses to von Frey stimulation of the plantar hindpaws. 
      Morphine (6mg/kg) and gabapentin (100mg/kg) elicited an almost complete reversal 
      of SMIR-evoked mechanical hypersensitivity. In contrast, MK-801 (0.1mg/kg) did 
      not affect SMIR-evoked mechanical hypersensitivity. Contralateral hindpaw 
      responses to von Frey stimulation were unaffected by SMIR surgery or any drug 
      treatment. In conclusion, the SMIR model displays persistent mechanical 
      hypersensitivity that is reversible by morphine or gabapentin treatment. As 
      previously demonstrated, SMIR-evoked pain is not driven by neuronal damage and 
      these data show that NMDA receptor activation does not play a role in the 
      maintenance of SMIR-evoked pain. This study further demonstrates the value of the 
      SMIR model as a tool to understand persistent postoperative/postsurgical pain 
      mechanisms and evaluate potential treatments.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Flatters, Sarah J L
AU  - Flatters SJ
AD  - Wolfson Centre for Age-Related Diseases, Centre for Integrative Biomedicine, 
      King's College London, Hodgkin Building, Guy's Campus, London SE11UL, UK. 
      sarah.flatters@kcl.ac.uk
LA  - eng
GR  - BB/E527098/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100424
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amines)
RN  - 0 (Analgesics)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Amines/therapeutic use
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Chronic Disease
MH  - Cyclohexanecarboxylic Acids/therapeutic use
MH  - *Dermatologic Surgical Procedures
MH  - *Disease Models, Animal
MH  - Dizocilpine Maleate/therapeutic use
MH  - Gabapentin
MH  - Hindlimb
MH  - Hyperalgesia/drug therapy/physiopathology
MH  - Male
MH  - Morphine/therapeutic use
MH  - Muscle, Skeletal/*surgery
MH  - Pain Measurement
MH  - Pain, Postoperative/drug therapy/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Touch
MH  - gamma-Aminobutyric Acid/therapeutic use
EDAT- 2010/04/27 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/03/16 00:00 [received]
PHST- 2010/04/14 00:00 [revised]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S0304-3940(10)00480-5 [pii]
AID - 10.1016/j.neulet.2010.04.033 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Jun 14;477(1):43-7. doi: 10.1016/j.neulet.2010.04.033. Epub 
      2010 Apr 24.