PMID- 20417862
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100426
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 199
IP  - 1
DP  - 2010 May
TI  - A novel t(5;11)(q31;p15) involving the NUP98 gene on 11p15 is associated with a 
      loss of the EGR1 gene on 5q31 in a patient with acute myeloid leukemia.
PG  - 9-14
LID - 10.1016/j.cancergencyto.2010.01.008 [doi]
AB  - To date, at least 25 translocations involving the NUP98 gene and different 
      partner genes have been reported in the literature. Here, we describe a novel 
      reciprocal t(5;11)(q31;p15) involving NUP98, as revealed by conventional 
      karyotypic analysis using R-banding technique and fluorescence in situ 
      hybridization (FISH) using a BAC RP11-120E20 probe and whole chromosome paint 
      probes for chromosomes 5 and 11 in a 77-year-old woman who was diagnosed as 
      having de novo acute myeloid leukemia. The patient received two courses of 
      intensive combined chemotherapy but did not reach complete remission. She 
      eventually died from the progressive disease, surviving for only 1 month after 
      diagnosis. FISH analysis using WCP5 together with BAC RP11-878F9 or RP11-155N22 
      demonstrated that the breakpoint of chromosome 5 is located on 5q31. In addition, 
      the EGR1 gene was unexpectedly found to be lost in the FISH study using EGR1 
      (red)/D5S23, D5S721 (green) dual-color probe. We supposed that the fusion gene 
      created by t(5;11)(q31;p15) consisting of the NUP98 and its partner gene, as well 
      as the loss of the EGR1 gene, may play a cooperative role in leukemogenesis. The 
      partner gene of NUP98 in t(5;11)(q31;p15) is unclear at this time. Further 
      molecular study is required to identify this partner gene in our patient.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Wang, Yong
AU  - Wang Y
AD  - The First Affiliated Hospital of Soochow University, Jiangsu Institutes of 
      Hematology, Suzhou, PR China.
FAU - Xue, Yongquan
AU  - Xue Y
FAU - Chen, Suning
AU  - Chen S
FAU - Wu, Yafang
AU  - Wu Y
FAU - Pan, Jinlan
AU  - Pan J
FAU - Zhang, Jun
AU  - Zhang J
FAU - Shen, Juan
AU  - Shen J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (EGR1 protein, human)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (Nup98 protein, human)
SB  - IM
MH  - Aged
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Early Growth Response Protein 1/*genetics
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Nuclear Pore Complex Proteins/*genetics
MH  - *Translocation, Genetic
EDAT- 2010/04/27 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/04/27 06:00
PHST- 2009/09/05 00:00 [received]
PHST- 2010/01/07 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0165-4608(10)00035-X [pii]
AID - 10.1016/j.cancergencyto.2010.01.008 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2010 May;199(1):9-14. doi: 
      10.1016/j.cancergencyto.2010.01.008.