PMID- 20418295
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20100528
IS  - 1526-7598 (Electronic)
IS  - 0003-2999 (Linking)
VI  - 110
IP  - 5
DP  - 2010 May 1
TI  - Genetic predisposition to natural rubber latex allergy differs between health 
      care workers and high-risk patients.
PG  - 1310-7
LID - 10.1213/ANE.0b013e3181d7e31c [doi]
AB  - BACKGROUND: In health care workers, the natural rubber latex (NRL) allergy 
      phenotype has been shown to be associated with promoter polymorphisms in 
      interleukins 13 and 18 (IL13 and IL18) when compared with nonatopic controls. 
      However, it is not known whether high-risk patient populations, such as those 
      born with neural tube defects or genitourinary abnormalities, demonstrate a 
      heightened propensity toward the same genetic/immunologic risk factors that have 
      been reported for health care workers. In this study, we tested the hypothesis 
      that single-nucleotide polymorphisms in genes encoding IL13 and IL18 occur at an 
      increased frequency in NRL allergic patients with spina bifida (SB) or bladder 
      exstrophy (BE). METHODS: One hundred twenty subjects (40 SB, 40 BE, and 40 
      control) were screened using a clinical history questionnaire and NRL-specific 
      immunoglobulin E (IgE) antibody measurements in the blood. Genomic DNA was 
      extracted from peripheral blood lymphocytes and analyzed for single-nucleotide 
      polymorphisms in candidate genes of interest. Univariate and multivariate 
      analyses were performed to identify significant variables with significance 
      defined as P < 0.05. RESULTS: Sensitization (IgE antibody positivity) to NRL 
      allergens was associated with atopic history and number of prior operations and 
      was prevented by the avoidance of NRL beginning at birth. However, unlike health 
      care workers, the NRL allergy phenotype was not significantly associated with 
      promoter polymorphisms in IL13 or IL18 when comparing NRL allergic SB and BE 
      patients with nonsensitized patients and with atopic and nonatopic controls. 
      CONCLUSIONS: In patients born with SB or BE, environmental factors seem to play a 
      greater role in the development of NRL sensitization and overt allergic symptoms 
      than the IL polymorphisms in IL13 and IL18 previously shown to be associated with 
      NRL allergy in health care workers.
FAU - Monitto, Constance L
AU  - Monitto CL
AD  - Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University 
      School of Medicine, Baltimore, MD 21287, USA. cmonitt1@jhmi.edu
FAU - Hamilton, Robert G
AU  - Hamilton RG
FAU - Levey, Eric
AU  - Levey E
FAU - Jedlicka, Anne E
AU  - Jedlicka AE
FAU - Dziedzic, Amanda
AU  - Dziedzic A
FAU - Gearhart, John P
AU  - Gearhart JP
FAU - Boyadjiev, Simeon A
AU  - Boyadjiev SA
FAU - Brown, Robert H
AU  - Brown RH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Health Personnel/*statistics & numerical data
MH  - Humans
MH  - Hypersensitivity, Immediate/genetics
MH  - Interleukin-13/genetics/immunology
MH  - Interleukin-18/genetics/immunology
MH  - Latex Hypersensitivity/*genetics/immunology
MH  - Male
MH  - Occupational Exposure
MH  - Patients/*statistics & numerical data
MH  - Polymorphism, Genetic/genetics
MH  - Population
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Risk
MH  - Young Adult
EDAT- 2010/04/27 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - 110/5/1310 [pii]
AID - 10.1213/ANE.0b013e3181d7e31c [doi]
PST - ppublish
SO  - Anesth Analg. 2010 May 1;110(5):1310-7. doi: 10.1213/ANE.0b013e3181d7e31c.