PMID- 20418972
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100625
LR  - 20211020
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Print)
IS  - 0019-5154 (Linking)
VI  - 55
IP  - 1
DP  - 2010
TI  - Impact of HLA-G in the outcome of vitiligo in Tunisian patients.
PG  - 25-8
LID - 10.4103/0019-5154.60346 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA) system in the skin coordinates the 
      pigmentation and immune response and could be implicated in the pathogenesis of 
      vitiligo. Human leukocyte antigen HLA-G is a nonclassic, major histocompatibility 
      complex class I molecule expressed in the extravillous cytotrophoblast at the 
      feto-maternal interface. It is known to protect the fetus from maternal cellular 
      immunity. Analogically, it could be implicated in the pathogenesis of autoimmune 
      diseases such as vitiligo. AIMS: To compare the expression of HLA-G between 
      vitiligo patients and healthy controls. MATERIALS AND METHODS: In the present 
      study, 22 vitiligo patients and 24 healthy controls were investigated to look for 
      a possible correlation between HLA-G expression and this pathology. Expression of 
      HLA-G in cutaneous biopsy specimens was investigated by immunohistochemical 
      analysis. RESULTS: HLA-G was detected in the biopsy specimens of 3 (13%) out of 
      22 patients. This number was significantly higher in healthy controls 18 (75%) 
      out of 24 as compared to vitiligo patients (P < 0.001). CONCLUSION: There is 
      significant negative correlation between HLA-G expression and vitiligo. In our 
      mind, upregulation of HLA-G expression in lesional skin could be local 
      (superficial expression) or systemic (soluble HLA-G isoforms) compensation to 
      restore normal pigmentation in lesions.
FAU - Jalel, Akrem
AU  - Jalel A
AD  - Research Unit on the Antioxidant Compounds, Oxidative Stress, Trace Elements and 
      Metabolic Diseases, Department of Physiology, Ecole Superieure des Sciences et 
      Techniques de la Sante de Tunis, Tunisia. akrem_jalel@yahoo.fr
FAU - Ridha, Aouadi
AU  - Ridha A
FAU - Laurent, Duboisier
AU  - Laurent D
FAU - Philippe, Moureaux
AU  - Philippe M
FAU - Hamdaoui, M H
AU  - Hamdaoui MH
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC2856368
OTO - NOTNLM
OT  - HLA-G
OT  - Vitiligo
OT  - immune tolerogenesis
COIS- Conflict of Interest: Nil.
EDAT- 2010/04/27 06:00
MHDA- 2010/04/27 06:01
PMCR- 2010/01/01
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/04/27 06:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - IJD-55-25 [pii]
AID - 10.4103/0019-5154.60346 [doi]
PST - ppublish
SO  - Indian J Dermatol. 2010;55(1):25-8. doi: 10.4103/0019-5154.60346.