PMID- 20419392
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20211020
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 34
IP  - 2
DP  - 2011 Apr
TI  - White blood cell subtypes after STEMI: temporal evolution, association with 
      cardiovascular magnetic resonance--derived infarct size and impact on outcome.
PG  - 73-84
LID - 10.1007/s10753-010-9209-0 [doi]
AB  - The evolution of white blood cells after ST elevation myocardial infarction 
      (STEMI) and their association with infarct size and major adverse cardiac events 
      (MACE) remains unclear. Two hundred eleven patients underwent CMR after STEMI. 
      Infarct mass (grams) was determined. Neutrophil, lymphocyte, and monocyte counts 
      (x1,000 cells/ml) were measured upon arrival and at 12, 24, 48, 72, and 96 h. 
      Patients with large infarctions (3rd tertile >/= 28.5 g vs. 1st and 2nd 
      tertiles < 28.5 g) showed a larger neutrophil count at 12 h (14.8 +/- 4.8 vs. 
      11.4 +/- 3.3, p < 0.0001) and an increased monocyte count (maximum at 24 h 
      (0.65[0.50-0.91] vs. 0.55[0.42-0.71], p = 0.004)) but no difference in lymphocyte 
      count. Neutrophil count at 12 h independently predicted large infarctions (OR 
      1.14, 95%CI [1.04-1.26], p = 0.008). During follow-up (median 504 days), 25 MACE 
      occurred. Neutrophil count at 96 h independently predicted MACE (HR 1.2, 95%CI 
      [1.1-1.4], p = 0.003). Large infarctions show a marked neutrophil peak and an 
      increasing monocyte count. Neutrophil count independently predicts large 
      infarctions and MACE.
FAU - Husser, Oliver
AU  - Husser O
AD  - Department of Cardiology, Hospital Clinico Universitario, INCLIVA, Universidad de 
      Valencia, Blasco Ibanez 17, Valencia, Spain.
FAU - Bodi, Vicente
AU  - Bodi V
FAU - Sanchis, Juan
AU  - Sanchis J
FAU - Nunez, Julio
AU  - Nunez J
FAU - Mainar, Luis
AU  - Mainar L
FAU - Chorro, Francisco Javier
AU  - Chorro FJ
FAU - Lopez-Lereu, Maria Pilar
AU  - Lopez-Lereu MP
FAU - Monmeneu, Jose Vicente
AU  - Monmeneu JV
FAU - Chaustre, Fabian
AU  - Chaustre F
FAU - Forteza, Maria J
AU  - Forteza MJ
FAU - Trapero, Isabel
AU  - Trapero I
FAU - Dasi, Francisco
AU  - Dasi F
FAU - Benet, Isabel
AU  - Benet I
FAU - Riegger, Gunter A J
AU  - Riegger GA
FAU - Llacer, Angel
AU  - Llacer A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angioplasty
MH  - Biomarkers
MH  - Cardiac Catheterization
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - Lymphocytes/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Monocytes/physiology
MH  - Myocardial Infarction/*blood/*pathology/physiopathology
MH  - Myocardium/pathology
MH  - Neutrophils/*physiology
MH  - Stents
MH  - Treatment Outcome
EDAT- 2010/04/27 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1007/s10753-010-9209-0 [doi]
PST - ppublish
SO  - Inflammation. 2011 Apr;34(2):73-84. doi: 10.1007/s10753-010-9209-0.