PMID- 20420568
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20190917
IS  - 1873-4316 (Electronic)
IS  - 1389-2010 (Linking)
VI  - 11
IP  - 5
DP  - 2010 Aug
TI  - Myocardial expression of TNF-alpha, IL-1beta, IL-6, IL-8, IL-10 and MCP-1 after a 
      single MDMA dose administered in a rat model.
PG  - 413-20
AB  - Indirect effects of 3,4-methylenedioxy-N-methylamphetamine (MDMA) and metabolites 
      on the cardiac cells are well-known, the mechanism(s) underlying direct 
      MDMA-induced cardiotoxicity remaining to be clarified. To better understand the 
      immuno-inflammatory phenomena accompanying the cardiac alterations during MDMA 
      administration, we conducted a study in an in vivo animal model to evaluate the 
      cellular morphological alterations related to the biological response between 
      MDMA administration and inflammatory cytokines (tumor necrosis factor-alpha, 
      IL-1beta, IL-6, 8, 10, and monocyte chemotactic protein-1). A total of 25 male 
      rats were used. The effects were evaluated at 6, 16 and 24 hours after a single 
      dose MDMA administered (20 mg/kg i.p.). We found high levels of the 
      cardioinhibitory cytokines in rat heart after 3 and 6 hs from MDMA 
      administration. Strongest reaction was observed at 24 hs for TNF-alpha, IL-1beta, 
      IL-6, 8, 10 and for MCP-1. Furthermore, we still determined the presence of MDMA 
      and MDA in the plasma of rats treated with MDMA intra-peritoneal single 
      injection; it was present as early at 6 hs and still present 24 hs after 
      treatment. Western blot analysis in cardiac samples demonstrated the IL-1beta and 
      IL-6 reactions in rats died spontaneously at fourth hour. The rise of the 
      selective cardioinhibitory cytokines may be interpreted as the adaptive response 
      of jeopardized myocardium to the cardiac dysfunction resulting from MDMA 
      injection.
FAU - Neri, Margherita
AU  - Neri M
AD  - Department of Forensic Pathology, University of Foggia, Ospedale Colonnello 
      D'Avanzo, 71100 Foggia, Italy.
FAU - Bello, Stefania
AU  - Bello S
FAU - Bonsignore, Alessandro
AU  - Bonsignore A
FAU - Centini, Fabio
AU  - Centini F
FAU - Fiore, Carmela
AU  - Fiore C
FAU - Foldes-Papp, Zeno
AU  - Foldes-Papp Z
FAU - Turillazzi, Emanuela
AU  - Turillazzi E
FAU - Fineschi, Vittorio
AU  - Fineschi V
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Curr Pharm Biotechnol
JT  - Current pharmaceutical biotechnology
JID - 100960530
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Heart/*drug effects
MH  - Humans
MH  - Immunologic Factors/*metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Metabolic Clearance Rate/drug effects
MH  - Models, Animal
MH  - Myocardium/*metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
EDAT- 2010/04/28 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/01/01 00:00 [received]
PHST- 2010/02/10 00:00 [accepted]
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - BSP/CPB/E-Pub/0075-11-5 [pii]
AID - 10.2174/138920110791591517 [doi]
PST - ppublish
SO  - Curr Pharm Biotechnol. 2010 Aug;11(5):413-20. doi: 10.2174/138920110791591517.