PMID- 20421390
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20211020
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 207
IP  - 5
DP  - 2010 May 10
TI  - GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th 
      effector cell differentiation after subcutaneous immunization.
PG  - 953-61
LID - 10.1084/jem.20091844 [doi]
AB  - Dendritic cells (DCs) play an important role in CD4(+) T helper (Th) cell 
      differentiation and in the initiation of both protective and pathogenic immunity. 
      Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a DC growth factor 
      critical for the induction of experimental autoimmune encephalomyelitis (EAE) and 
      other autoimmune diseases, yet its mechanism of action in vivo is not fully 
      defined. We show that GM-CSF is directly required for the accumulation of 
      radiosensitive dermal-derived langerin(+)CD103(+) DCs in the skin and peripheral 
      lymph nodes under steady-state and inflammatory conditions. Langerin(+)CD103(+) 
      DCs stimulated naive myelin-reactive T cells to proliferate and produce IFN-gamma 
      and IL-17. They were superior to other DC subsets in inducing expression of T-bet 
      and promoting Th1 cell differentiation. Ablation of this subset in vivo conferred 
      resistance to EAE. The current report reveals a previously unidentified role for 
      GM-CSF in DC ontogeny and identifies langerin(+)CD103(+) DCs as an important 
      subset in CD4(+) T cell-mediated autoimmune disease.
FAU - King, Irah L
AU  - King IL
AD  - Interdepartmental Graduate Program in Neuroscience, University of Rochester 
      School of Medicine and Dentistry, Rochester, NY 14642, USA.
FAU - Kroenke, Mark A
AU  - Kroenke MA
FAU - Segal, Benjamin M
AU  - Segal BM
LA  - eng
GR  - R01 NS047687/NS/NINDS NIH HHS/United States
GR  - R01 NS057670/NS/NINDS NIH HHS/United States
GR  - NS047687-01A1/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100426
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Surface)
RN  - 0 (Cd207 protein, mouse)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - 0 (alpha E integrins)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*genetics
MH  - Antigens, Surface/*genetics
MH  - Autoimmune Diseases/immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/deficiency/genetics/*physiology
MH  - Immunization/methods
MH  - Integrin alpha Chains/*genetics
MH  - Lectins, C-Type/*genetics
MH  - Lymph Nodes/immunology
MH  - Mannose-Binding Lectins/*genetics
MH  - Mice
MH  - Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics
MH  - Skin/*immunology
MH  - Th1 Cells/cytology/*immunology
MH  - Th2 Cells/cytology/*immunology
PMC - PMC2867280
EDAT- 2010/04/28 06:00
MHDA- 2010/06/09 06:00
PMCR- 2010/11/10
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PHST- 2010/11/10 00:00 [pmc-release]
AID - jem.20091844 [pii]
AID - 20091844 [pii]
AID - 10.1084/jem.20091844 [doi]
PST - ppublish
SO  - J Exp Med. 2010 May 10;207(5):953-61. doi: 10.1084/jem.20091844. Epub 2010 Apr 
      26.