PMID- 20421625
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20131121
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Spring
TI  - Association of hypophosphatemia with failure-to-wean from mechanical ventilation.
PG  - 144-8
AB  - Severe hypophosphatemia is known to be associated with respiratory failure, but 
      there are few studies that specifically examine the relationship between serum 
      phosphorus concentration and failure to wean patients from mechanical 
      ventilation. This study investigated the association between hypophosphatemia and 
      weaning failure in patients in two medical intensive care units (ICU). The study 
      was conducted in a prospectively developed cohort of 66 patients being treated 
      with ventilatory support and in whom 193 weaning trials were attempted. 
      Ultimately, all 66 subjects were successfully weaned. A cross-sectional analysis 
      was conducted on serum phosphorus levels and success or failure to wean the 
      patients from ventilators. At the time of the successful weaning attempts (n = 
      66), the subjects' serum phosphorus concentrations (mean +/- SD) were 1.18 +/- 
      0.27 mmol/L, whereas at all failed weaning attempts (n = 127) serum phosphorus 
      concentrations averaged 1.06 +/- 0.31 mmol/L (p = 0.008). Subjects with 
      phosphorus concentrations below the reference interval (RI) in our laboratory 
      (<0.80 mmol/L) had greater risk for weaning failure compared to subjects with 
      phosphorus concentrations at or above the RI (relative risk = 1.18; 95% 
      confidence interval = 1.06 to 1.32; p = 0.01). Serum calcium concentrations were 
      not significantly different at the time of successful weaning compared to those 
      at failed weaning attempts. This study indicates that there is an association 
      between hypophosphatemia and failure-to-wean from mechanical ventilation in ICU 
      patients on ventilatory support.
FAU - Alsumrain, Mohammad H
AU  - Alsumrain MH
AD  - Department of Critical Care Medicine, Saint Michael's Medical Center, Newark, New 
      Jersey, USA.
FAU - Jawad, Sami Abdul
AU  - Jawad SA
FAU - Imran, Nashat B
AU  - Imran NB
FAU - Riar, Sandeep
AU  - Riar S
FAU - DeBari, Vincent A
AU  - DeBari VA
FAU - Adelman, Marc
AU  - Adelman M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 27YLU75U4W (Phosphorus)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hypophosphatemia/blood/*complications
MH  - Male
MH  - Middle Aged
MH  - Phosphorus/blood
MH  - ROC Curve
MH  - Respiration, Artificial/*adverse effects
MH  - Respiratory Insufficiency/blood/*complications
EDAT- 2010/04/28 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 40/2/144 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2010 Spring;40(2):144-8.