PMID- 20422977
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20100428
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Feb
TI  - [Expression and significance of IGF-IR and PKC in laryngeal squamous cell 
      carcinoma].
PG  - 152-5
AB  - OBJECTIVE: To investigate the expression of IGF-IR and PKC and their clinical 
      significance in laryngeal squamous cell carcinoma(LSCC). METHOD: The expression 
      of IGF-IR and PKC protein were detected by immunohistochemistry and Western blot 
      in 60 cases of LSCC, 25 cases of adjacent non-tumorous laryngeal epithelium and 
      10 cases of normal laryngeal epithelium. RESULT: The positive rate of IGF-IR and 
      PKC expression in LSCC were significantly higher than that in normal laryngeal 
      epithelium and adjacent non-tumorous laryngeal epithelium (P < 0.05). IGF-IR 
      positive expression were increased more in cases with stage III-IV, cervical 
      lymph node metastasis and well differentiation than that in cases with stage 
      I-II, non-lymph node metastasis and poor/mediate differentiation, respectively (P 
      < 0.05). The positive rate of PKC in LSCC were correlated with clinical stage and 
      cervical lymph node metastasis. There was a correlation between the expression of 
      IGF-IR and PKC in LSCC. CONCLUSION: The overexpression of IGF-IR and PKC in the 
      laryngeal carcinoma may play an important role in the carcinogenesis and 
      development of LSCC. It is suggested that detecting the expression of IGF-IR and 
      PKC can be used for early diagnosis and treatment of LSCC.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, 430030, 
      China.
FAU - Pan, Song
AU  - Pan S
FAU - Zhou, Yuanhong
AU  - Zhou Y
FAU - Yu, Zhihua
AU  - Yu Z
FAU - Liu, Lisi
AU  - Liu L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Protein Kinase C/*metabolism
MH  - Receptor, IGF Type 1/*metabolism
EDAT- 2010/04/29 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Feb;24(4):152-5.