PMID- 20423087
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20100520
IS  - 1520-4804 (Electronic)
IS  - 0022-2623 (Linking)
VI  - 53
IP  - 10
DP  - 2010 May 27
TI  - Chitosan derivatives as novel potential heparin reversal agents.
PG  - 4141-7
LID - 10.1021/jm1001666 [doi]
AB  - In emergency cases anticoagulant action of heparin needs to be stopped 
      instantaneously, which is usually achieved by intravenous administration of 
      protamine sulfate (PS). However, PS shows many adverse effects. The objective of 
      the present work was to find out if chitosan (Ch) and a cationically modified 
      chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), may 
      be applied for heparin reversal. For chitosan the efficiency of unfractionated 
      heparin (UFH) binding decreases with increasing pH while for cationically 
      modified chitosan heparin binding is efficient even for high pH values. 
      Complexation of UFH and low-molecular-weight heparin (LMWH) by cationically 
      modified chitosan in the aqueous solution at pH = 7.4 was studied. Complexes of 
      the modified chitosan with UFH are smaller and of lower dispersity than those 
      with PS. Cationically modified chitosan was found to bind both UFH and LMWH. The 
      complex formation capability of cationically modified chitosan is comparable to 
      that of PS.
FAU - Kaminski, Kamil
AU  - Kaminski K
AD  - Faculty of Chemistry, Jagiellonian University, Krakow, Poland.
FAU - Szczubialka, Krzysztof
AU  - Szczubialka K
FAU - Zazakowny, Karolina
AU  - Zazakowny K
FAU - Lach, Radoslaw
AU  - Lach R
FAU - Nowakowska, Maria
AU  - Nowakowska M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (N-(2-hydroxypropyl)-3-trimethylammonium chitosan)
RN  - 0 (Protamines)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 9005-49-6 (Heparin)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Anticoagulants/adverse effects/*chemistry
MH  - Chitosan/*analogs & derivatives/*chemistry
MH  - Conductometry
MH  - Heparin/adverse effects/*chemistry
MH  - Heparin, Low-Molecular-Weight/adverse effects/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Light
MH  - Nanoparticles
MH  - Protamines/chemistry
MH  - Quaternary Ammonium Compounds/*chemistry
MH  - Scattering, Radiation
EDAT- 2010/04/29 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - 10.1021/jm1001666 [doi]
PST - ppublish
SO  - J Med Chem. 2010 May 27;53(10):4141-7. doi: 10.1021/jm1001666.