PMID- 20423879 OWN - NLM STAT- MEDLINE DCOM- 20110922 LR - 20100428 IS - 1673-4254 (Print) IS - 1673-4254 (Linking) VI - 30 IP - 4 DP - 2010 Apr TI - [Correlation of adiponectin, monocyte chemoattractant protein-1, and endothelial function to vascular remodeling in coronary in-stent restenosis]. PG - 912-4 AB - OBJECTIVE: To investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis. METHODS: RI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis. RESULTS: Compared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1. CONCLUSION: The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors. FAU - Wang, Zhi-bing AU - Wang ZB AD - Department of Cardiology, Nanshan People's Hospital of Shenzhen, Shenzhen 518052, China. wang264486@hotmail.com FAU - Liu, Jun AU - Liu J FAU - Chen, Shao-yuan AU - Chen SY FAU - Su, You-su AU - Su YS FAU - Xie, Pei-yi AU - Xie PY FAU - Fang, Hong-cheng AU - Fang HC LA - chi PT - English Abstract PT - Journal Article PL - China TA - Nan Fang Yi Ke Da Xue Xue Bao JT - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JID - 101266132 RN - 0 (Adiponectin) RN - 0 (Chemokine CCL2) SB - IM MH - Adiponectin/*blood MH - Adult MH - Aged MH - Angioplasty, Balloon, Coronary MH - Chemokine CCL2/*blood MH - Coronary Disease/blood/physiopathology/therapy MH - Coronary Restenosis/*blood/etiology MH - Endothelium, Vascular/*physiopathology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Stents/*adverse effects EDAT- 2010/04/29 06:00 MHDA- 2011/09/23 06:00 CRDT- 2010/04/29 06:00 PHST- 2010/04/29 06:00 [entrez] PHST- 2010/04/29 06:00 [pubmed] PHST- 2011/09/23 06:00 [medline] PST - ppublish SO - Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):912-4.