PMID- 20424638
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20211020
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 30
IP  - 9
DP  - 2010 Sep
TI  - Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic 
      cerebral ischemia.
PG  - 1651-60
LID - 10.1038/jcbfm.2010.50 [doi]
AB  - Hyperbaric oxygen (HBO) and normobaric hyperoxia (NBO) protect the brain 
      parenchyma and the cerebral microcirculation against ischemia. We studied their 
      effect on secondary hemorrhage after thrombolysis in two thromboembolic middle 
      cerebral artery occlusion (MCAO) (tMCAO) models. Beginning 60 minutes after tMCAO 
      with either thrombin-induced thromboemboli (TT) or calcium-induced thromboemboli 
      (CT), spontaneously hypertensive rats (n=96) breathed either air, 100% O(2) 
      (NBO), or 100% O(2) at 3 bar (HBO) for 1 hour. Immediately thereafter, 
      recombinant tissue plasminogen activator (rt-PA, 9 mg/kg) was injected. Although 
      significant reperfusion was observed after thrombolysis in TT-tMCAO, vascular 
      occlusion persisted in CT-tMCAO. In TT-tMCAO, NBO and HBO significantly reduced 
      diffusion-weighted imaging-magnetic resonance imaging (MRI) lesion volume and 
      postischemic blood-brain barrier (BBB) permeability on postcontrast T1-weighted 
      images. NBO and, significantly more potently, HBO reduced macroscopic hemorrhage 
      on T2* MRI and on corresponding postmortem cryosections. Oxygen therapy lowered 
      hemoglobin content and attenuated activation of matrix metalloproteinases in the 
      ischemic hemisphere. In contrast, NBO and HBO failed to reduce infarct size in CT 
      but both decreased BBB damage and microscopic hemorrhagic transformation. Only 
      HBO reduced hemoglobin extravasation in the ischemic hemisphere. In conclusion, 
      NBO and HBO decrease infarct size after thromboembolic ischemia only if 
      recanalization is successful. As NBO and HBO also reduce postthrombolytic 
      intracerebral hemorrhage, combining the two with thrombolysis seems promising.
FAU - Sun, Li
AU  - Sun L
AD  - Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, 
      Germany.
FAU - Zhou, Wei
AU  - Zhou W
FAU - Mueller, Christian
AU  - Mueller C
FAU - Sommer, Clemens
AU  - Sommer C
FAU - Heiland, Sabine
AU  - Heiland S
FAU - Bauer, Alexander T
AU  - Bauer AT
FAU - Marti, Hugo H
AU  - Marti HH
FAU - Veltkamp, Roland
AU  - Veltkamp R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100428
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Hemoglobins)
RN  - 9000-70-8 (Gelatin)
RN  - EC 3.4.21.5 (Thrombin)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain Ischemia/*complications/*drug therapy/pathology
MH  - Cerebral Hemorrhage/etiology/pathology/*prevention & control
MH  - Data Interpretation, Statistical
MH  - Erythrocytes/physiology
MH  - Fibrinolytic Agents/*adverse effects
MH  - Gelatin
MH  - Hemoglobins/metabolism
MH  - Image Processing, Computer-Assisted
MH  - Infarction, Middle Cerebral Artery/complications/drug therapy/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Matrix Metalloproteinase 9/biosynthesis
MH  - *Oxygen Inhalation Therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thrombin
MH  - Thromboembolism/chemically induced/*complications/*drug therapy
PMC - PMC2949252
EDAT- 2010/04/29 06:00
MHDA- 2010/10/20 06:00
PMCR- 2011/09/01
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - jcbfm201050 [pii]
AID - 10.1038/jcbfm.2010.50 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2010 Sep;30(9):1651-60. doi: 10.1038/jcbfm.2010.50. 
      Epub 2010 Apr 28.