PMID- 20425697
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20220331
IS  - 0022-9032 (Print)
IS  - 0022-9032 (Linking)
VI  - 68
IP  - 4
DP  - 2010 Apr
TI  - Prediction of long-term outcome after primary percutaneous coronary intervention 
      for acute anterior myocardial infarction.
PG  - 393-400
AB  - BACKGROUND: Despite the widespread use of reperfusion methods, the long-term 
      outcome after primary percutaneous coronary intervention (PCI) is variable, and 
      accurate risk stratification is of clinical importance. AIM: To assess the 
      predictors of long term outcome after PCI for acute anterior myocardial 
      infarction (AMI). METHODS: One hundred and twenty-seven consecutive patients 
      undergoing PCI within 12 hours from the onset of the first AMI were enrolled. 
      Troponin I, CK-MB, creatinine, NT-proBNP, echocardiographic left ventricular (LV) 
      function, myocardial contrast perfusion, results of coronary angiography, ECG, 
      24-hour Holter ECG, and T-wave alternans (TWA) were analysed as predictors of 
      major adverse cardiac events (MACE), defined as death, non-fatal reinfarction, 
      sustained ventricular tachycardia, and rehospitalisation for decompensated heart 
      failure. Patients were followed up for two years. RESULTS: Twenty-seven patients 
      developed MACE. The best predictive model for MACE consisted of impaired 
      perfusion (MCE, myocardial contrast echocardiography), higher CK-MB at 24 hours, 
      discharge NT-proBNP, and non-negative TWA. The combination of elevated creatinine 
      level, decreased LV ejection fraction, and a non-negative TWA proved the best for 
      identification of patients at risk of cardiac death. The best multivariate model 
      for predicting heart failure hospitalisation consisted of higher 24-hour CK-MB, 
      discharge NT-proBNP, impaired perfusion and prolonged duration of ST elevation. 
      CONCLUSIONS: Our study showed that the rate of MACE in patients with anterior 
      ST-segment elevation myocardial infarction undergoing primary PCI at two years 
      follow-up is low. A combined assessment of myocardial contrast perfusion, TWA, 
      CK-MB and discharge NT-proBNP seems to optimally predict patients at risk of 
      MACE.
FAU - Wita, Krystian
AU  - Wita K
AD  - Department of Cardiology, Medical University of Silesia, Katowice, Poland.
FAU - Filipecki, Artur
AU  - Filipecki A
FAU - Szydlo, Krzysztof
AU  - Szydlo K
FAU - Turski, Maciej
AU  - Turski M
FAU - Tabor, Zbigniew
AU  - Tabor Z
FAU - Wrobel, Wojciech
AU  - Wrobel W
FAU - Elzbieciak, Marek
AU  - Elzbieciak M
FAU - Lelek, Michal
AU  - Lelek M
FAU - Bochenek, Tomasz
AU  - Bochenek T
FAU - Trusz-Gluza, Maria
AU  - Trusz-Gluza M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
SB  - IM
CIN - Kardiol Pol. 2010 Apr;68(4):401-2. PMID: 20425698
MH  - Angiography
MH  - *Angioplasty, Balloon, Coronary
MH  - Disease-Free Survival
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*diagnosis/*therapy
MH  - Prognosis
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2010/04/29 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PST - ppublish
SO  - Kardiol Pol. 2010 Apr;68(4):393-400.