PMID- 20426625
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20220330
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 13
IP  - 2-3
DP  - 2010 Apr-Jun
TI  - HLA and KIR frequencies in Sicilian Centenarians.
PG  - 314-8
LID - 10.1089/rej.2009.0984 [doi]
AB  - Several studies suggest that human longevity appears to be linked inextricably 
      with optimal functioning of the immune system, suggesting that specific genetic 
      determinants may reside in loci that regulate the immune response, as human 
      leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) genes. 
      It has been suggested that longevity is associated with positive selection of 
      alleles (i.e., HLA-DR11) or haplotypes (i.e., HLA-B8,DR3) that confer resistance 
      to infectious disease(s). On the other hand, the cytolytic activity of natural 
      killer (NK) cells is controlled by activating and inhibitory cell-surface 
      receptors, including KIR. The genetic diversity of the KIR loci with respect to 
      successful aging has been analyzed only in one study performed in the Irish 
      population. Although two KIR genes (2DS3, 2DL5) displayed an initial increased 
      frequency in the aged group, the significance of this association was lost when 
      repeated in a second cohort. We have evaluated by polymerase chain 
      reaction-sequence-specific primers (PCR-SSP) HLA-DRB1 and KIR receptors/HLA 
      ligands frequencies in centenarians and controls from Sicily. Our results 
      demonstrate an increase of the HLA DRB1*18 allele in male centenarians (p = 
      0.0266, after Bonferroni correction). Concerning KIR, no significant difference 
      was observed after Bonferroni correction. However, our findings suggest that 
      HLA/KIR/longevity associations are population specific, being heavily affected by 
      the population-specific genetic and environmental history. This kind of study is 
      important to better understand aging and longevity, hence enhancing the planning 
      of antiaging strategies.
FAU - Listi, Florinda
AU  - Listi F
AD  - Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, 
      University of Palermo, Palermo, Italy.
FAU - Caruso, Calogero
AU  - Caruso C
FAU - Colonna-Romano, Giuseppina
AU  - Colonna-Romano G
FAU - Lio, Domenico
AU  - Lio D
FAU - Nuzzo, Domenico
AU  - Nuzzo D
FAU - Candore, Giuseppina
AU  - Candore G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - *Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-B8 Antigen/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Longevity/*genetics
MH  - Male
MH  - Receptors, KIR/*genetics
MH  - Sicily
EDAT- 2010/04/30 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/04/30 06:00
PHST- 2010/04/30 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1089/rej.2009.0984 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2010 Apr-Jun;13(2-3):314-8. doi: 10.1089/rej.2009.0984.