PMID- 20427497
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20151119
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 7
DP  - 2010 Jul
TI  - Soluble human leukocyte antigen-g expression and glucose tolerance in subjects 
      with different degrees of adiposity.
PG  - 3342-6
LID - 10.1210/jc.2009-2747 [doi]
AB  - CONTEXT: Type 2 diabetes mellitus (T2DM) and obesity are characterized by a 
      low-grade inflammation, which might be related to the development of insulin 
      resistance. Human leukocyte antigen-G (HLA-G) shows antiinflammatory and 
      tolerogenic properties, including the modulation of CD8+ T-cell cytotoxicity and 
      regulation of CD4+ T-lymphocyte function. These functions are partially shared 
      with IL-10, whose levels are reduced in insulin-resistant states. OBJECTIVE: The 
      aim was to explore the relationship between HLA-G and the metabolic and 
      inflammatory pattern of obesity or T2DM. PATIENTS AND MAIN OUTCOME MEASURES: 
      Soluble HLA-G, IL-6, and IL-10 were measured and related with metabolic and 
      biochemical parameters in 230 volunteers with normal glucose tolerance, impaired 
      glucose tolerance, or T2DM by oral glucose tolerance test. RESULTS: sHLA-G, 
      detected in 144 subjects (sHLA-G positive), was more frequent in T2DM or impaired 
      glucose tolerance subjects than in normal glucose tolerance (chi(2) =18.6; P < 
      0.0001), and its plasma levels increased progressively across the classes of 
      glucose tolerance. sHLA-G-positive individuals had higher body mass index, 
      systolic blood pressure, and cholesterol levels; a reduced degree of insulin 
      sensitivity; and almost 2-fold higher levels of IL-6, a cytokine related to 
      insulin sensitivity, whereas IL-10 was similar. In the sHLA-G-positive subgroup, 
      by a multivariate regression model, sHLA-G was significantly related to 2-h 
      glucose, the area under insulin curve, and IL-6 levels (multiple r(2) = 0.14; P < 
      0.001), independently of age, gender, and body mass index. CONCLUSIONS: A 
      frequent expression of sHLA-G, linked to a typical biomarker of insulin 
      resistance like IL-6, seems to characterize subjects with an impaired glucose 
      metabolism.
FAU - Solini, Anna
AU  - Solini A
AD  - Department of Internal Medicine, University of Pisa, Via Roma 67, I-56100 Pisa, 
      Italy. a.solini@med.unipi.it
FAU - Muscelli, Elza
AU  - Muscelli E
FAU - Stignani, Marina
AU  - Stignani M
FAU - Melchiorri, Loredana
AU  - Melchiorri L
FAU - Santini, Eleonora
AU  - Santini E
FAU - Rossi, Chiara
AU  - Rossi C
FAU - Astiarraga, Brenno Domingues
AU  - Astiarraga BD
FAU - Rizzo, Roberta
AU  - Rizzo R
FAU - Baricordi, Olavio Roberto
AU  - Baricordi OR
LA  - eng
PT  - Journal Article
DEP - 20100428
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adiposity/*physiology
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glucose Intolerance/*metabolism/physiopathology
MH  - Glucose Tolerance Test
MH  - HLA Antigens/*blood
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*blood
MH  - Humans
MH  - Insulin/blood
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*metabolism/physiopathology
MH  - Regression Analysis
MH  - Statistics, Nonparametric
EDAT- 2010/04/30 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/30 06:00
PHST- 2010/04/30 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - jc.2009-2747 [pii]
AID - 10.1210/jc.2009-2747 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Jul;95(7):3342-6. doi: 10.1210/jc.2009-2747. Epub 
      2010 Apr 28.