PMID- 20430078
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20240318
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 267
IP  - 1-2
DP  - 2010 Aug
TI  - Patterned tone sequences reveal non-linear interactions in auditory 
      spectrotemporal receptive fields in the inferior colliculus.
PG  - 96-110
LID - 10.1016/j.heares.2010.04.005 [doi]
AB  - Linear measures of auditory receptive fields do not always fully account for a 
      neuron's response to spectrotemporally-complex signals such as 
      frequency-modulated sweeps (FM) and communication sounds. A possible source of 
      this discrepancy is cross-frequency interactions, common response properties 
      which may be missed by linear receptive fields but captured using two-tone 
      masking. Using a patterned tonal sequence that included a balanced set of all 
      possible tone-to-tone transitions, we have here combined the spectrotemporal 
      receptive field with two-tone masking to measure spectrotemporal response maps 
      (STRM). Recording from single units in the mustached bat inferior colliculus, we 
      found significant non-linear interactions between sequential tones in all sampled 
      units. In particular, tone-pair STRMs revealed three common features not visible 
      in linear single-tone STRMs: 1) two-tone facilitative interactions, 2) 
      frequency-specific suppression, and 3) post-stimulatory suppression in the 
      absence of spiking. We also found a correlative relationship between these 
      nonlinear receptive field features and sensitivity for different rates and 
      directions of FM sweeps, dynamic features found in many vocalizations, including 
      speech. The overwhelming prevalence of cross-frequency interactions revealed by 
      this technique provides further evidence of the central auditory system's role as 
      a pattern-detector, and underscores the need to include nonlinearity in measures 
      of the receptive field.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Brimijoin, W Owen
AU  - Brimijoin WO
AD  - Department of Brain and Cognitive Sciences, College of Arts, Science, and 
      Engineering, University of Rochester, Rochester, NY 14627, USA. 
      owen@ihr.gla.ac.uk
FAU - O'Neill, William E
AU  - O'Neill WE
LA  - eng
GR  - R01-DC03717/DC/NIDCD NIH HHS/United States
GR  - R01 DC003717/DC/NIDCD NIH HHS/United States
GR  - T32 MH019942/MH/NIMH NIH HHS/United States
GR  - MC_U135097131/MRC_/Medical Research Council/United Kingdom
GR  - 5 T32 MH19942-07/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100427
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Auditory Pathways/*physiology
MH  - Auditory Perception/physiology
MH  - Chiroptera
MH  - Inferior Colliculi/*physiology
MH  - Male
MH  - Models, Animal
MH  - Neurons/physiology
MH  - *Nonlinear Dynamics
MH  - Pattern Recognition, Physiological/*physiology
PMC - PMC3978381
MID - NIHMS208135
EDAT- 2010/05/01 06:00
MHDA- 2010/10/29 06:00
PMCR- 2014/04/08
CRDT- 2010/05/01 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/04/06 00:00 [revised]
PHST- 2010/04/06 00:00 [accepted]
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
PHST- 2014/04/08 00:00 [pmc-release]
AID - S0378-5955(10)00191-7 [pii]
AID - 10.1016/j.heares.2010.04.005 [doi]
PST - ppublish
SO  - Hear Res. 2010 Aug;267(1-2):96-110. doi: 10.1016/j.heares.2010.04.005. Epub 2010 
      Apr 27.