PMID- 20430502
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Print)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 1
DP  - 2010 Jul
TI  - Life course socioeconomic position is associated with inflammatory markers: the 
      Framingham Offspring Study.
PG  - 187-95
LID - 10.1016/j.socscimed.2010.03.012 [doi]
AB  - Associations between life course socioeconomic position (SEP) and novel 
      biological risk markers for coronary heart disease such as inflammatory markers 
      are not well understood. Most studies demonstrate inverse associations of life 
      course SEP with C-reactive protein (CRP), interleukin-6 (IL-6) and fibrinogen, 
      however little is known about associations between life course SEP and other 
      inflammatory markers including intercellular adhesion molecule-1 (ICAM-1), tumor 
      necrosis factor II (TNFR2), lipoprotein phospholipase A2 (Lp-PLA2) activity, 
      monocyte chemoattractant protein-1 (MCP-1) or P-selectin. The objectives of this 
      analysis were to determine whether three life course SEP frameworks 
      ("accumulation of risk", "social mobility" and "sensitive periods") are 
      associated with the aforementioned inflammatory markers. We examined 1413 
      Framingham Offspring Study participants (mean age 61.2+/-8.6 years, 54% women), 
      using multivariable regression analyses. In age- and sex-adjusted regression 
      analyses, cumulative SEP ("accumulation of risk" SEP framework), for low vs. high 
      SEP, was inversely associated with CRP, IL-6, ICAM-1, TNFR2, Lp-PLA2 activity, 
      MCP-1 and fibrinogen. We found that there were few consistent trends between 
      social mobility trajectories and most inflammatory markers. Own educational 
      attainment was inversely associated with 7 of 8 studied inflammatory markers, 
      while father's education, father's occupation and own occupation were inversely 
      associated with 4, 5 and 4 inflammatory markers, respectively, in age- and 
      sex-adjusted analyses. The strengths of association between SEP and inflammatory 
      markers were typically substantially accounted for by CHD risk markers (smoking, 
      body mass index, systolic blood pressure, total:HDL cholesterol ratio, fasting 
      glucose, medications, depressive symptomatology) suggesting these may be 
      important mechanisms that explain associations between SEP and the studied 
      inflammatory markers.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Loucks, Eric B
AU  - Loucks EB
AD  - Department of Community Health, Epidemiology Section, Brown University, Rhode 
      Island, United States. eric.loucks@brown.edu
FAU - Pilote, Louise
AU  - Pilote L
FAU - Lynch, John W
AU  - Lynch JW
FAU - Richard, Hugues
AU  - Richard H
FAU - Almeida, Nisha D
AU  - Almeida ND
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
FAU - Murabito, Joanne M
AU  - Murabito JM
LA  - eng
GR  - R01 HL064753-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL076784/HL/NHLBI NIH HHS/United States
GR  - R01 HL064753-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL076784-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL064753-01/HL/NHLBI NIH HHS/United States
GR  - HL064753/HL/NHLBI NIH HHS/United States
GR  - HL076784/HL/NHLBI NIH HHS/United States
GR  - R01 HL076784-05/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321-04/AG/NIA NIH HHS/United States
GR  - R01 AG028321-05/AG/NIA NIH HHS/United States
GR  - R01 HL076784-01/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321-03/AG/NIA NIH HHS/United States
GR  - R01 AG028321-01/AG/NIA NIH HHS/United States
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - R01 AG028321-02/AG/NIA NIH HHS/United States
GR  - R01 HL076784-03/HL/NHLBI NIH HHS/United States
GR  - AG028321/AG/NIA NIH HHS/United States
GR  - R01 HL076784-04/HL/NHLBI NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - MOP81239/CAPMC/CIHR/Canada
GR  - R01 HL064753-02/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100323
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (P-Selectin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood
MH  - Biomarkers/*blood
MH  - Chemokine CCL2/blood
MH  - Cohort Studies
MH  - Coronary Disease/*blood/epidemiology
MH  - Female
MH  - Humans
MH  - *Inflammation
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - P-Selectin/blood
MH  - Regression Analysis
MH  - Risk Factors
MH  - *Social Class
MH  - Social Mobility
MH  - Socioeconomic Factors
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC2895737
MID - NIHMS202396
EDAT- 2010/05/01 06:00
MHDA- 2010/07/28 06:00
PMCR- 2011/07/01
CRDT- 2010/05/01 06:00
PHST- 2009/04/06 00:00 [received]
PHST- 2010/01/21 00:00 [revised]
PHST- 2010/03/06 00:00 [accepted]
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0277-9536(10)00239-X [pii]
AID - 10.1016/j.socscimed.2010.03.012 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jul;71(1):187-95. doi: 10.1016/j.socscimed.2010.03.012. Epub 
      2010 Mar 23.