PMID- 20431065
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20211020
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Print)
IS  - 1079-5642 (Linking)
VI  - 30
IP  - 7
DP  - 2010 Jul
TI  - Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 
      levels, and the risk of coronary artery disease.
PG  - 1460-6
LID - 10.1161/ATVBAHA.110.205526 [doi]
AB  - OBJECTIVE: In humans, evidence about the association between levels of monocyte 
      chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 
      (CCL2), and risk of coronary artery disease (CAD) is contradictory. METHODS AND 
      RESULTS: We performed a nested case-control study in the prospective EPIC-Norfolk 
      cohort investigating the relationship between CCL2 single-nucleotide 
      polymorphisms (SNPs), MCP-1 concentrations, and the risk of future CAD. Cases 
      (n=1138) were apparently healthy men and women aged 45 to 79 years who developed 
      fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n=2237) were 
      matched by age, sex, and enrollment time. Using linear regression analysis no 
      association between CCL2 SNPs and MCP-1 serum concentrations became apparent, nor 
      did we find a significant association between MCP-1 serum levels and risk of 
      future CAD. Finally, Cox regression analysis showed no significant association 
      between CCL2 SNPs and the future CAD risk. In addition, we did not find any 
      robust associations between the CCL2 haplotypes and MCP-1 serum concentration or 
      future CAD risk. CONCLUSIONS: Our data do not support previous publications 
      indicating that MCP-1 is involved in the pathogenesis of CAD.
FAU - van Wijk, Diederik F
AU  - van Wijk DF
AD  - Department of Vascular Medicine, Academic Medical Center, Amsterdam, the 
      Netherlands. d.f.vanwijk@amc.uva.nl
FAU - van Leuven, Sander I
AU  - van Leuven SI
FAU - Sandhu, Manjinder S
AU  - Sandhu MS
FAU - Tanck, Michael W
AU  - Tanck MW
FAU - Hutten, Barbara A
AU  - Hutten BA
FAU - Wareham, Nicholas J
AU  - Wareham NJ
FAU - Kastelein, John J P
AU  - Kastelein JJ
FAU - Stroes, Erik S G
AU  - Stroes ES
FAU - Khaw, Kay-Tee
AU  - Khaw KT
FAU - Boekholdt, S Matthijs
AU  - Boekholdt SM
LA  - eng
GR  - A14136/CRUK_/Cancer Research UK/United Kingdom
GR  - A8257/CRUK_/Cancer Research UK/United Kingdom
GR  - G1000143/MRC_/Medical Research Council/United Kingdom
GR  - MC_U106179471/MRC_/Medical Research Council/United Kingdom
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
GR  - PG/08/094/26019/BHF_/British Heart Foundation/United Kingdom
GR  - G0801566/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100429
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Coronary Artery Disease/*genetics/immunology
MH  - England
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
PMC - PMC4210837
MID - EMS60672
OID - NLM: EMS60672
EDAT- 2010/05/01 06:00
MHDA- 2010/07/14 06:00
PMCR- 2014/10/28
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PHST- 2014/10/28 00:00 [pmc-release]
AID - ATVBAHA.110.205526 [pii]
AID - 10.1161/ATVBAHA.110.205526 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1460-6. doi: 
      10.1161/ATVBAHA.110.205526. Epub 2010 Apr 29.