PMID- 2043488
OWN - NLM
STAT- MEDLINE
DCOM- 19910717
LR  - 20200128
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 2
IP  - 3
DP  - 1991 Mar
TI  - Expression of transforming growth factor alpha (TGF alpha) in breast cancer.
PG  - 169-82
AB  - Transforming growth factor alpha (TGF alpha) is one growth factor that has been 
      circumstantially implicated in regulating the autocrine growth of breast cancer 
      cells. Expression of TGF alpha can be modulated by activated cellular 
      protooncogenes such as ras and by estrogens. For example, the epidermal growth 
      factor (EGF)-responsive normal NOG-8 mouse and human MCF-10A mammary epithelial 
      cell lines can be transformed with either a point-mutated c-Ha-ras protooncogene 
      or with a normal or point-mutated c-neu (erbB-2) protooncogene. In ras 
      transformed NOG-8 and MCF-10A cells but not in neu transformed cells there is a 
      loss in or an attenuated response to the mitogenic effects of EGF. This response 
      may be due in part to an enhanced production of endogenous TGF alpha that is 
      coordinately and temporally linked to the expression of the activated ras gene 
      and to the acquisition of transformation-associated properties in these cells. 
      TGF alpha mRNA and TGF alpha protein can also be detected in approximately 50-70% 
      of primary human breast tumors. In addition, approximately 2- to 3-fold higher 
      levels of biologically active and immunoreactive TGF alpha can also be detected 
      in the pleural effusions from breast cancer patients as compared with the TGF 
      alpha levels in the serous effusions of noncancer patients. Over-expression of a 
      full-length TGF alpha cDNA in NOG-8 and MCF-10A cells is capable of transforming 
      these cells. Finally, expression of TGF alpha mRNA and production of biologically 
      active TGF alpha protein is also found in normal rodent and human mammary 
      epithelial cells.
FAU - Ciardiello, F
AU  - Ciardiello F
AD  - Laboratory of Tumor Immunology and Biology, National Cancer Institute, National 
      Institutes of Health, Bethesda.
FAU - Kim, N
AU  - Kim N
FAU - McGeady, M L
AU  - McGeady ML
FAU - Liscia, D S
AU  - Liscia DS
FAU - Saeki, T
AU  - Saeki T
FAU - Bianco, C
AU  - Bianco C
FAU - Salomon, D S
AU  - Salomon DS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*metabolism
MH  - Cell Transformation, Neoplastic
MH  - Cells, Cultured
MH  - Gene Expression
MH  - Humans
MH  - Pleural Effusion/metabolism
MH  - Proto-Oncogenes/physiology
MH  - Transforming Growth Factor alpha/genetics/*metabolism
RF  - 112
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - S0923-7534(20)31416-2 [pii]
AID - 10.1093/oxfordjournals.annonc.a057897 [doi]
PST - ppublish
SO  - Ann Oncol. 1991 Mar;2(3):169-82. doi: 10.1093/oxfordjournals.annonc.a057897.