PMID- 20437050
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 267
IP  - 11
DP  - 2010 Nov
TI  - Heterotopic gastric mucosal patch of the esophagus is associated with higher 
      prevalence of laryngopharyngeal reflux symptoms.
PG  - 1793-9
LID - 10.1007/s00405-010-1259-2 [doi]
AB  - Laryngopharyngeal reflux (LPR) is common in clinical practice. Heterotopic 
      gastric mucosal patch of the proximal esophagus (HGMP) is reported to cause LPR 
      symptoms. This study assessed the prevalence of LPR symptoms and correlation with 
      the size of HGMP. Four hundred and sixty-two patients undergoing endoscopy were 
      carefully questioned regarding LPR symptoms experienced in the previous 12 weeks. 
      The size of the HGMP was assessed and documented during endoscopy. 
      Clinicopathological classifications were assigned (types I-V) accordingly. HGMP 
      [median one patch (range 1-3), median size 15 mm [3-35] was detected in 26 (19 
      HGM type I and 7 HGM type II] patients giving a prevalence of 5.6%. Among the 
      indications, there were significantly more LPR symptoms as referral indications 
      among patients with HGMP. There were no significant differences in the endoscopic 
      findings. On specific enquiries, significantly more HGMP patients had experienced 
      any LPR symptoms (73.1 vs. 25.9%, p < 0.001) specifically chronic cough (p = 
      0.002), throat discomfort/hoarseness (p < 0.001), globus sensation (p = 0.004), 
      regurgitation (p < 0.001). HGMP patients also had more heartburn (p = 0.001). 
      Larger HGMP (>/= 15 mm) was only associated with more chronic cough (p = 0.022). In 
      conclusion, patients with HGMP have significantly more LPR symptoms. However, 
      most were mild and detected through specific enquiries. Interestingly, the size 
      of HGMP did not significantly affect the prevalence of LPR symptoms.
FAU - Chong, Vui Heng
AU  - Chong VH
AD  - Gastroenterology Unit, Department of Medicine, Raja Isteri Pengiran Anak Saleha 
      Hospital, Bandar Seri Begawan BA1710, Brunei Darussalam. chongvuih@yahoo.co.uk
FAU - Jalihal, Anand
AU  - Jalihal A
LA  - eng
PT  - Journal Article
DEP - 20100501
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Biopsy
MH  - Chi-Square Distribution
MH  - Choristoma/*pathology
MH  - Esophageal Sphincter, Upper/*pathology
MH  - Esophagoscopy
MH  - Female
MH  - *Gastric Mucosa
MH  - Humans
MH  - Laryngopharyngeal Reflux/*etiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Statistics, Nonparametric
EDAT- 2010/05/04 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/05/04 06:00
PHST- 2009/12/16 00:00 [received]
PHST- 2010/04/15 00:00 [accepted]
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1007/s00405-010-1259-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2010 Nov;267(11):1793-9. doi: 
      10.1007/s00405-010-1259-2. Epub 2010 May 1.