PMID- 20439954
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20211020
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 82
IP  - 5
DP  - 2010 May
TI  - Community effectiveness of intermittent preventive treatment for infants (IPTi) 
      in rural southern Tanzania.
PG  - 772-81
LID - 10.4269/ajtmh.2010.09-0207 [doi]
AB  - Intermittent preventive treatment of malaria in infants (IPTi) with 
      sulphadoxine-pyrimethamine shows evidence of efficacy in individually randomized, 
      controlled trials. In a large-scale effectiveness study, IPTi was introduced in 
      April 2005 by existing health staff through routine contacts in 12 randomly 
      selected divisions out of 24 in 6 districts of rural southern Tanzania. Coverage 
      and effects on malaria and anemia were estimated through a representative survey 
      in 2006 with 600 children aged 2-11 months. Coverage of IPTi was 47-76% depending 
      on the definition. Using an intention to treat analysis, parasitemia prevalence 
      was 31% in intervention and 38% in comparison areas (P = 0.06). In a "per 
      protocol" analysis of children who had recently received IPTi, parasite 
      prevalence was 22%, 19 percentage points lower than comparison children (P = 
      0.01). IPTi can be implemented on a large scale by existing health service staff, 
      with a measurable population effect on malaria, within 1 year of launch.
FAU - Armstrong Schellenberg, Joanna R M
AU  - Armstrong Schellenberg JR
AD  - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT. 
      Joanna.schellenberg@lshtm.ac.uk
FAU - Shirima, Kizito
AU  - Shirima K
FAU - Maokola, Werner
AU  - Maokola W
FAU - Manzi, Fatuma
AU  - Manzi F
FAU - Mrisho, Mwifadhi
AU  - Mrisho M
FAU - Mushi, Adiel
AU  - Mushi A
FAU - Mshinda, Hassan
AU  - Mshinda H
FAU - Alonso, Pedro
AU  - Alonso P
FAU - Tanner, Marcel
AU  - Tanner M
FAU - Schellenberg, David M
AU  - Schellenberg DM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antimalarials)
SB  - IM
MH  - Anemia/prevention & control
MH  - Antimalarials/*administration & dosage/therapeutic use
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Infant
MH  - Malaria/epidemiology/*prevention & control
MH  - Male
MH  - Rural Population
MH  - Socioeconomic Factors
MH  - Tanzania/epidemiology
PMC - PMC2861388
EDAT- 2010/05/05 06:00
MHDA- 2010/05/28 06:00
PMCR- 2011/05/01
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - 82/5/772 [pii]
AID - 10.4269/ajtmh.2010.09-0207 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2010 May;82(5):772-81. doi: 10.4269/ajtmh.2010.09-0207.