PMID- 20442057
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20211203
IS  - 1232-1087 (Print)
IS  - 1232-1087 (Linking)
VI  - 23
IP  - 1
DP  - 2010
TI  - Residential proximity to environmental sources of persistent organic pollutants 
      and first-time hospitalizations for myocardial infarction with comorbid diabetes 
      mellitus: a 12-year population-based study.
PG  - 5-13
LID - 10.2478/v10001-010-0010-y [doi]
AB  - OBJECTIVES: Environmental exposure to persistent organic pollutants (POPs) has 
      been associated with an increased risk of both acute myocardial infarction (AMI) 
      and diabetes mellitus (DM). A study of first-time hospitalizations for AMI with 
      DM as a comorbidity in populations presumed to be exposed or not exposed on the 
      basis of residence near POPs sites was conducted to investigate whether exposure 
      to POPs increases the environmental burden of disease. MATERIALS AND METHODS: We 
      examined the association between residential proximity to environmental sources 
      of POPs and hospitalization rates for first-time AMI with comorbid DM in 31,428 
      patients aged 25-74 years, using the New York Statewide Planning and Research 
      Cooperative System data for a 12-year period (1993-2004). Environmental exposure 
      status was assessed based on the zip code of residence. Adjusted relative risks 
      (RR) of AMI hospitalization were estimated by multivariate Poisson regression. 
      RESULTS: Hospitalization rates for first-time AMI with comorbid DM were 
      significantly greater in populations living near POPs sites (adjusted RR = 1.169, 
      95% CI: 1.014-1.347, p < 0.05). These rates were also significantly higher in 
      African Americans than in Caucasians (adjusted RR = 1.902, 95% CI: 1.659-2.180, p 
      < 0.001), in males (adjusted RR = 1.767, 95% CI: 1.695-1.843, p < 0.001), and for 
      older ages (p for trend < 0.001). These findings, consistent with established 
      non-modifiable risk factors, support the plausibility of our model. CONCLUSIONS: 
      Residential proximity to environmental sources of POPs is associated with a 
      significant increase in hospitalization rates for first-time AMI with comorbid 
      DM, compared to respective rates in populations not exposed to POPs.
FAU - Sergeev, Alexander V
AU  - Sergeev AV
AD  - Ohio University, School of Public Health Sciences and Professions, Athens, OH 
      45701, USA. sergeev@ohio.edu
FAU - Carpenter, David O
AU  - Carpenter DO
LA  - eng
GR  - TW000636/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Int J Occup Med Environ Health
JT  - International journal of occupational medicine and environmental health
JID - 9437093
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Comorbidity
MH  - Diabetes Mellitus/*chemically induced/epidemiology
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*chemically induced/epidemiology
MH  - Organic Chemicals/*toxicity
MH  - Racial Groups
MH  - Residence Characteristics/*statistics & numerical data
MH  - Sex Distribution
EDAT- 2010/05/06 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/05/06 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - L13K685980731590 [pii]
AID - 10.2478/v10001-010-0010-y [doi]
PST - ppublish
SO  - Int J Occup Med Environ Health. 2010;23(1):5-13. doi: 10.2478/v10001-010-0010-y.