PMID- 2044209
OWN - NLM
STAT- MEDLINE
DCOM- 19910718
LR  - 20131121
IS  - 0092-6213 (Print)
IS  - 0092-6213 (Linking)
VI  - 33
IP  - 3
DP  - 1991 Mar
TI  - Survival factors in a canine septic shock model.
PG  - 178-82
AB  - Physiological indicators of tissue perfusion in a canine septic shock model have 
      been examined. An early death (ED) group and a combined late death and survivor 
      group (LDS) were defined and the corresponding data compared. It was found that 
      the LDS group had less reductions in mean systemic arterial pressure (P less than 
      0.05), transcutaneous oxygen pressure (P less than 0.05), and red blood cell 
      deformability (P less than 0.001); a smaller increase in hematocrit (P less than 
      0.05); and a lower concentration of white blood cells (P less than 0.05), 
      relative to the ED group, at 6 hr after an infusion of Escherichia coli 
      organisms. These results suggest that dogs in the LDS group have better tissue 
      perfusion than those in the early death ED group. Post-treatment of dogs with 
      pentoxifylline did not improve survival time or enhance flow factors.
FAU - Chung, T W
AU  - Chung TW
AD  - Department of Chemical Engineering, University of Oklahoma, Norman 73019.
FAU - O'Rear, E A
AU  - O'Rear EA
FAU - Whitsett, T L
AU  - Whitsett TL
FAU - Hinshaw, L B
AU  - Hinshaw LB
FAU - Smith, M A
AU  - Smith MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Shock
JT  - Circulatory shock
JID - 0414112
RN  - S88TT14065 (Oxygen)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - *Disease Models, Animal
MH  - Dogs
MH  - Erythrocyte Deformability
MH  - *Escherichia coli Infections
MH  - Female
MH  - Hematocrit
MH  - Leukocyte Count
MH  - Male
MH  - Oxygen/blood
MH  - Pentoxifylline/therapeutic use
MH  - Shock, Septic/blood/*mortality/physiopathology
MH  - Survival Rate
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
PST - ppublish
SO  - Circ Shock. 1991 Mar;33(3):178-82.