PMID- 20443735
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20171116
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 201
IP  - 12
DP  - 2010 Jun 15
TI  - Clinical significance of cloned expansion and CD5 down-regulation in Epstein-Barr 
      Virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic 
      lymphohistiocytosis.
PG  - 1923-32
LID - 10.1086/652752 [doi]
AB  - Epstein-Barr virus (EBV) is the pathogen that most commonly triggers 
      infection-associated hemophagocytic lymphohistiocytosis (HLH) and ectopically 
      infects CD8(+) T cells in EBV-associated HLH (EBV-HLH). We recently described an 
      EBV-HLH patient who had a clonally expanded population of EBV-infected CD8(+) T 
      cells with CD5 down-regulation. To determine whether this finding could serve as 
      a useful marker for EBV-HLH, we investigated 5 additional patients. We found a 
      significant increase in the subpopulation of CD8(+) T cells with CD5 
      down-regulation and bright human leukocyte antigen (HLA)-DR expression in all 
      patients with EBV-HLH but not in patients with infectious mononucleosis or in 
      control subjects. Such T cells were frequently found to be larger cells that 
      stained positive for a specific T cell receptor VB. We also demonstrated that 
      those cells were the major cellular target of EBV, and their numbers 
      progressively declined in parallel with the serum ferritin levels. All together, 
      our findings reveal the immunophenotypic characteristics of EBV-infected CD8(+) T 
      cells and may provide a valuable tool for the diagnosis of EBV-HLH.
FAU - Toga, Akiko
AU  - Toga A
AD  - Department of Pediatrics, School of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
FAU - Wada, Taizo
AU  - Wada T
FAU - Sakakibara, Yasuhisa
AU  - Sakakibara Y
FAU - Mase, Shintaro
AU  - Mase S
FAU - Araki, Raita
AU  - Araki R
FAU - Tone, Yumi
AU  - Tone Y
FAU - Toma, Tomoko
AU  - Toma T
FAU - Kurokawa, Toshiro
AU  - Kurokawa T
FAU - Yanagisawa, Ryu
AU  - Yanagisawa R
FAU - Tamura, Kentaro
AU  - Tamura K
FAU - Nishida, Naonori
AU  - Nishida N
FAU - Taneichi, Hiromichi
AU  - Taneichi H
FAU - Kanegane, Hirokazu
AU  - Kanegane H
FAU - Yachie, Akihiro
AU  - Yachie A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (CD5 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - CD5 Antigens/*biosynthesis
MH  - CD8-Positive T-Lymphocytes/*immunology/*virology
MH  - Child
MH  - Child, Preschool
MH  - Down-Regulation
MH  - Epstein-Barr Virus Infections/complications/*immunology
MH  - Female
MH  - HLA-DR Antigens/biosynthesis
MH  - Herpesvirus 4, Human/immunology/*pathogenicity
MH  - Humans
MH  - Infant
MH  - Lymphohistiocytosis, Hemophagocytic/*immunology/*virology
MH  - Male
MH  - Receptors, Antigen, T-Cell/biosynthesis
MH  - Young Adult
EDAT- 2010/05/07 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 10.1086/652752 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Jun 15;201(12):1923-32. doi: 10.1086/652752.