PMID- 20444153
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20101115
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 21
IP  - 8
DP  - 2010 Dec
TI  - Allergy, total serum immunoglobulin E, and airflow in children and adolescents in 
      TENOR.
PG  - 1157-65
LID - 10.1111/j.1399-3038.2010.01065.x [doi]
AB  - In children and adolescents with difficult-to-treat asthma, few data exist 
      characterizing the relationships between basic patient characteristics (e.g., 
      age, sex) and atopic indicators in asthma. These associations were examined in 
      The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens 
      (TENOR), an observational study of a large cohort of patients with severe or 
      difficult-to-treat asthma. To characterize allergy patterns and the relationship 
      between total serum immunoglobulin E (IgE) and airflow in young patients with 
      severe or difficult-to-treat asthma. A total of 1261 patients from the TENOR 
      study were stratified into four age groups at baseline (6-8, 9-11, 12-14, and 
      15-17 yr). The objective was to characterize allergy patterns and the 
      relationship between total serum immunoglobulin E (IgE) and ratio of 
      pre-bronchodilator forced expiratory volume in 1 second to forced vital capacity 
      (FEV(1) /FVC) in young patients with severe or difficult-to-treat asthma. The 
      chi-square test for categorical variables and analysis of variance for continuous 
      variables were used to identify significant differences among age groups. 
      Multivariable linear regression was used to evaluate the association between IgE 
      and FEV(1) /FVC. Allergic rhinitis was reported in approximately two-thirds of 
      patients. Up to 25% of patients had atopic dermatitis, which differed across age 
      groups in boys (p < 0.05). Positive allergen skin test rate differed across age 
      groups in boys (p < 0.05). Rates of asthma triggers were higher and differed 
      across age groups in girls (p < 0.05), particularly around menarche (12-14 yr). 
      IgE levels were higher in boys and differed across age groups in boys (p < 0.01) 
      and girls (p < 0.05). IgE was associated with a lower FEV(1) /FVC after adjusting 
      for age and sex (p < 0.01). Severe or difficult-to-treat asthma in children and 
      adolescents is characterized by high frequencies of comorbid allergic diseases, 
      allergen sensitization, and high IgE levels. This burden is amplified by the 
      association of more airflow limitation with higher IgE levels, suggesting the 
      need for allergy evaluations.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Haselkorn, Tmirah
AU  - Haselkorn T
AD  - Genentech, Inc., South San Francisco, California 94080, USA. 
      haselkorn.tmirah@gene.com
FAU - Szefler, Stanley J
AU  - Szefler SJ
FAU - Simons, F E R
AU  - Simons FE
FAU - Zeiger, Robert S
AU  - Zeiger RS
FAU - Mink, David R
AU  - Mink DR
FAU - Chipps, Bradley E
AU  - Chipps BE
FAU - Borish, Larry
AU  - Borish L
FAU - Wong, Dennis A
AU  - Wong DA
CN  - TENOR Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Allergens/immunology/*metabolism
MH  - Asthma/diagnosis/*epidemiology/*immunology/physiopathology
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/*epidemiology/*immunology/physiopathology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Prevalence
MH  - Respiratory Function Tests
MH  - Sex Factors
MH  - Skin Tests
EDAT- 2010/05/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - PAI1065 [pii]
AID - 10.1111/j.1399-3038.2010.01065.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2010 Dec;21(8):1157-65. doi: 
      10.1111/j.1399-3038.2010.01065.x.