PMID- 20444170
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20221207
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 21
IP  - 2 Pt 2
DP  - 2010 Mar
TI  - Increased serum thymic stromal lymphopoietin in children with atopic dermatitis.
PG  - e457-60
LID - 10.1111/j.1399-3038.2009.00919.x [doi]
AB  - The present study investigated the relationship between serum thymic stromal 
      lymphopoietin (TSLP) levels and the presence and severity of atopic dermatitis 
      (AD). Serum TSLP levels, blood eosinophil counts, and serum total and specific 
      immunoglobulin E (IgE) levels were measured in 232 children. Subjects were 
      characterized as having atopic eczema (AE; n=75), non-atopic eczema (NAE; n=70), 
      or normal controls (n=87). Serum TSLP levels in children with AD were 
      significantly higher than normal controls but there were no differences in 
      children with atopic and non-atopic eczema. However, serum TSLP levels in 
      children with AD were not significantly correlated with disease severity, blood 
      eosinophil counts and serum total IgE levels. Our findings show an association 
      between TSLP and AD including both AE and NAE. It is suggested that TSLP may play 
      a contributory role in the pathogenesis of AD regardless of the presence of 
      atopy.
CI  - Copyright (c) 2009 John Wiley & Sons A/S
FAU - Lee, Eun Byoul
AU  - Lee EB
AD  - Department of Pediatrics and Institute of Allergy, BK21 Project for Medical 
      Science, Research Center for Human Natural Defense System, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Kim, Kyung Won
AU  - Kim KW
FAU - Hong, Jung Yeon
AU  - Hong JY
FAU - Jee, Hye Mi
AU  - Jee HM
FAU - Sohn, Myung Hyun
AU  - Sohn MH
FAU - Kim, Kyu-Earn
AU  - Kim KE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Dermatitis, Atopic/metabolism/*physiopathology
MH  - Eczema/metabolism/physiopathology
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Severity of Illness Index
MH  - Thymic Stromal Lymphopoietin
EDAT- 2010/05/07 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - PAI919 [pii]
AID - 10.1111/j.1399-3038.2009.00919.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e457-60. doi: 
      10.1111/j.1399-3038.2009.00919.x.