PMID- 20444671
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20220317
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 118
IP  - 9
DP  - 2010 Sep
TI  - Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested 
      case-control study.
PG  - 1235-42
LID - 10.1289/ehp.0901480 [doi]
AB  - BACKGROUND: Low doses of some persistent organic pollutants (POPs) associate 
      cross-sectionally with type 2 diabetes, whereas associations with high POP 
      exposures are inconsistent. OBJECTIVES: We investigated whether several POPs 
      prospectively predict type 2 diabetes within the Coronary Artery Risk Development 
      in Young Adults (CARDIA) cohort. METHODS: Participants in this nested 
      case-control study were diabetes free in 1987-1988. By 2005-2006, the 90 controls 
      remained free of diabetes, whereas the 90 cases developed diabetes. Using serum 
      collected in 1987-1988, we measured 8 organochlorine pesticides, 22 
      polychlorinated biphenyl congeners (PCBs), and 1 polybrominated biphenyl (PBB). 
      We compared POP concentrations from CARDIA and the National Health and Nutrition 
      Examination Survey (NHANES) in 2003-2004. We computed odds ratios (ORs) for 
      incident diabetes using logistic regression analysis. RESULTS: Chlorinated POPs 
      in CARDIA in 1987-1988 were much higher than corresponding NHANES 2003-2004 
      concentrations. POPs showed nonlinear associations with diabetes risk. The 
      highest risk was observed in the second quartiles of trans-nonachlor, 
      oxychlordane, mirex, highly chlorinated PCBs, and PBB153-a finding that suggests 
      low-dose effects. We concentrated risk by summing these POPs and isolated very 
      low concentrations of multiple POPs in the lowest sextile of the sum. The 
      adjusted OR in the second sextile vs. the lowest sextile was 5.3 overall and 20.1 
      for body mass index > or = 30 kg/m2. CONCLUSIONS: Several POPs at low doses 
      similar to current exposure levels may increase diabetes risk, possibly through 
      endocrine disruption. Certain POPs may a play a role in the current epidemic of 
      diabetes, which has been attributed to obesity.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Steffes, Michael W
AU  - Steffes MW
FAU - Sjodin, Andreas
AU  - Sjodin A
FAU - Jones, Richard S
AU  - Jones RS
FAU - Needham, Larry L
AU  - Needham LL
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
LA  - eng
GR  - R01 HL053560/HL/NHLBI NIH HHS/United States
GR  - R01-HL-53560/HL/NHLBI NIH HHS/United States
GR  - N01-HC-95095/HC/NHLBI NIH HHS/United States
GR  - N01-HC-48050/HC/NHLBI NIH HHS/United States
GR  - N01HC95095/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48049/HC/NHLBI NIH HHS/United States
GR  - N01HC48050/HL/NHLBI NIH HHS/United States
GR  - N01HC48047/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48048/HC/NHLBI NIH HHS/United States
GR  - N01HC48048/HL/NHLBI NIH HHS/United States
GR  - N01-HC-48047/HC/NHLBI NIH HHS/United States
GR  - N01HC48049/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100505
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Air Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 12789-03-6 (Chlordan)
RN  - 27304-13-8 (oxychlordane)
RN  - 3734-49-4 (nonachlor)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Air Pollutants/*adverse effects/*blood
MH  - Case-Control Studies
MH  - Chlordan/adverse effects/analogs & derivatives/blood
MH  - Diabetes Mellitus, Type 2/*blood/*etiology
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/adverse effects/blood
MH  - Male
MH  - Polychlorinated Biphenyls/adverse effects/blood
MH  - Young Adult
PMC - PMC2944083
EDAT- 2010/05/07 06:00
MHDA- 2010/12/16 06:00
PMCR- 2010/09/01
CRDT- 2010/05/07 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/05/05 00:00 [accepted]
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - ehp-118-1235 [pii]
AID - 10.1289/ehp.0901480 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2010 Sep;118(9):1235-42. doi: 10.1289/ehp.0901480. Epub 
      2010 May 5.