PMID- 20444922
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211020
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 7
DP  - 2010 Jul
TI  - The effect on glucagon, glucagon-like peptide-1, total and acyl-ghrelin of 
      dietary fats ingested with and without potato.
PG  - 3385-91
LID - 10.1210/jc.2009-2559 [doi]
AB  - INTRODUCTION: We are interested in the metabolic response to ingested 
      macronutrients and the interaction between macronutrients in meals. Recently, we 
      have determined the insulin and glucose response to ingestion of lard, olive oil, 
      or safflower oil, fat sources varying in fatty acid composition and carbohydrate 
      (CHO), in the form of potato. OBJECTIVE: Our aim was to determine the effect of 
      these dietary fats ingested alone or with potato on glucagon, glucagon-like 
      peptide-1 (GLP-1) (7-37 and 7-36 amide), and total and acyl-ghrelin 
      concentrations. METHODS: Healthy subjects ingested 25 g fat (lard, olive oil, or 
      safflower oil), 50 g CHO (potato), 25 g fat with 50 g CHO, or water only. 
      Glucagon, GLP-1 (7-37 and 7-36 amide), and total and acyl-ghrelin responses were 
      determined over 4 h. RESULTS: All fats when ingested alone increased glucagon. 
      Glucagon increases were dramatically attenuated when fats were ingested with the 
      potato. GLP-1 increased after all meals, but was greatest when fats were ingested 
      alone. The fat-stimulated increase was completely negated when fats were ingested 
      with potato. Both acyl and total ghrelin decreased when only fats were ingested, 
      as expected. When potato was ingested with any of the fats, the fat-induced 
      decrease in acyl-ghrelin response also was essentially negated. Paradoxically, 
      ghrelin increased when potato alone was ingested. CONCLUSIONS: The current data 
      indicate that the glucagon, GLP-1 and ghrelin responses to ingested fats, varying 
      in fatty acid composition, are significantly affected by co-ingestion of CHO. 
      Overall, the interaction between ingested foods in general is likely to be 
      complex.
FAU - Radulescu, Angela
AU  - Radulescu A
AD  - Endocrine, Metabolism, and Nutrition Section (111G), Veterans Affairs Medical 
      Center, Minneapolis, MN 55417, USA.
FAU - Gannon, Mary C
AU  - Gannon MC
FAU - Nuttall, Frank Q
AU  - Nuttall FQ
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100505
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Ghrelin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Area Under Curve
MH  - Body Mass Index
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Eating
MH  - Female
MH  - Ghrelin/*blood
MH  - Glucagon/*blood
MH  - Glucagon-Like Peptide 1/*blood
MH  - Humans
MH  - Male
MH  - Radioimmunoassay
MH  - Solanum tuberosum/*metabolism
MH  - Time Factors
PMC - PMC3213865
EDAT- 2010/05/07 06:00
MHDA- 2010/07/27 06:00
PMCR- 2011/07/01
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - jc.2009-2559 [pii]
AID - 7400 [pii]
AID - 10.1210/jc.2009-2559 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Jul;95(7):3385-91. doi: 10.1210/jc.2009-2559. Epub 
      2010 May 5.