PMID- 20448129
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20151119
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 96
IP  - 10
DP  - 2010 May
TI  - Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity 
      in idiopathic recurrent acute pericarditis.
PG  - 779-84
LID - 10.1136/hrt.2009.187138 [doi]
AB  - BACKGROUND: Idiopathic recurrent acute pericarditis (IRAP) is a rare disease of 
      suspected, yet unproved, immune-mediated origin. The finding of serum 
      heart-specific autoantibodies in IRAP would strengthen the autoimmune hypothesis 
      and provide aetiology-specific non-invasive biomarkers. Objective To assess 
      frequency of serum anti-heart (AHA), anti-intercalated-disk (AIDA) and 
      non-cardiac-specific autoantibodies and their clinical and instrumental 
      correlates in patients with IRAP. Patients 40 consecutive patients with IRAP, 25 
      male, aged 37+/-16 years, representing a large single-centre cohort collected at 
      a referral centre over a long time period (median 5 years, range 1-22 years). 
      Control groups included patients with non-inflammatory cardiac disease (NICD) 
      (n=160), ischaemic heart failure (n=141) and normal subjects (n=270). METHODS: 
      AHA (organ-specific, cross-reactive 1 and 2 types) and AIDA were detected in 
      serum samples from patients, at last follow-up, and control subjects by indirect 
      immunofluorescence (IIF) on human myocardium and skeletal muscle. 
      Non-cardiac-specific autoantibodies were detected by IIF, and anti-Ro/SSA, 
      anti-La/SSB by ELISA. RESULTS: The frequencies of cross-reactive 1 AHA and of 
      AIDA were higher (50%; 25%) in IRAP than in NICD (4%; 4%), ischaemic (1%; 2%) or 
      normal subjects (3%; 0%) (p=0.0001). AHA and/or AIDA were found in 67.5% patients 
      with IRAP. Of the non-cardiac-specific antibodies, only antinuclear 
      autoantibodies at titre > or =1/160 were more common in IRAP (5%) versus normal 
      (0.5%, p<0.04). AIDA in IRAP were associated with a higher number of recurrences 
      (p=0.01) and hospitalisations (p=0.0001), high titre (1/80 or higher) AHA with a 
      higher number of recurrences (p=0.02). CONCLUSIONS: The detection of AHA and of 
      AIDA supports the involvement of autoimmunity in the majority of patients with 
      IRAP.
FAU - Caforio, A L P
AU  - Caforio AL
AD  - Division of Cardiology, Department of Cardiological, Thoracic and Vascular 
      Sciences, Centro V Gallucci,University of Padova-Policlinico, Via Giustiniani, 2, 
      Padova 35128, Italy. alida.caforio@unipd.it
FAU - Brucato, A
AU  - Brucato A
FAU - Doria, A
AU  - Doria A
FAU - Brambilla, G
AU  - Brambilla G
FAU - Angelini, A
AU  - Angelini A
FAU - Ghirardello, A
AU  - Ghirardello A
FAU - Bottaro, S
AU  - Bottaro S
FAU - Tona, F
AU  - Tona F
FAU - Betterle, C
AU  - Betterle C
FAU - Daliento, L
AU  - Daliento L
FAU - Thiene, G
AU  - Thiene G
FAU - Iliceto, S
AU  - Iliceto S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
CIN - Heart. 2010 May;96(10):734-5. PMID: 20448122
MH  - Acute Disease
MH  - Adult
MH  - Autoantibodies/*blood
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*immunology
MH  - Myocytes, Cardiac/immunology
MH  - Pericarditis/*immunology
MH  - Recurrence
MH  - Young Adult
EDAT- 2010/05/08 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 96/10/779 [pii]
AID - 10.1136/hrt.2009.187138 [doi]
PST - ppublish
SO  - Heart. 2010 May;96(10):779-84. doi: 10.1136/hrt.2009.187138.