PMID- 20449807
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 9
IP  - 2
DP  - 2010 Apr 27
TI  - Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung 
      cancer.
PG  - 750-5
LID - 10.4238/vol9-2gmr735 [doi]
AB  - The primary function of the human leukocyte antigen (HLA) system is to regulate 
      the immune response. Because of its important role in the immune response and its 
      high degree of polymorphism, the HLA system is associated with many diseases. We 
      examined the polymorphisms of HLA-A, B and DRB1 alleles in 100 unrelated patients 
      with lung carcinoma and in 438 unrelated normal controls of Han nationality from 
      North China, using sequence-based typing and PCR with sequence-specific primers. 
      We found that the frequencies of HLA-A*0201, A*2601, B*1518, B*3802, DRB1*0401, 
      DRB1*0402, and DRB1*1201 were higher in the lung carcinoma group than in the 
      normal control group. The P values were 0.035, 0.040, 0.001, 0.017, 0.014, 0.004, 
      and 0.019, respectively, and the odds ratio values were 1.052, 3.513, 4.047, 
      3.054, 4.237, 19.397, and 2.128, respectively. The frequency of HLA-DRB1*1302 was 
      lower in the lung carcinoma group than in the normal control group (P = 0.046, 
      odds ratio = 0.168). We concluded that patients with lung cancer and healthy 
      controls of Han nationality from North China differ in the frequencies of various 
      HLA alleles.
FAU - Yang, L
AU  - Yang L
AD  - Department of Thoracic Surgeon, Beijing Tuberculosis and Thoracic Tumor Research 
      Institute, Beijing, P.R. China.
FAU - Wang, L J
AU  - Wang LJ
FAU - Shi, G L
AU  - Shi GL
FAU - Ni, L
AU  - Ni L
FAU - Song, C X
AU  - Song CX
FAU - Zhang, Z X
AU  - Zhang ZX
FAU - Xu, S F
AU  - Xu SF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100427
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
RN  - 0 (HLA-DRB1*04:02 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency/genetics
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2010/05/08 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - gmr735 [pii]
AID - 10.4238/vol9-2gmr735 [doi]
PST - epublish
SO  - Genet Mol Res. 2010 Apr 27;9(2):750-5. doi: 10.4238/vol9-2gmr735.