PMID- 20449809
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 9
IP  - 2
DP  - 2010 Apr 27
TI  - Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer 
      in the Han nationality of North China.
PG  - 765-71
LID - 10.4238/vol9-2gmr740 [doi]
AB  - Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a 
      dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory 
      region (-2518A/G) can affect the level of MCP-1 expression. We examined the 
      polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) 
      and 82 unrelated healthy controls of Han nationality in North China using 
      PCR-RFLP. We found that the distributions of AA, AG and GG genotypes of 
      MCP-1-2518 were significantly different in NSCLC patients compared to controls 
      (chi(2) = 10.106, P = 0.006). There was a significant increase in the frequency 
      of the AA genotype (odds ratio (OR) = 3.138, chi(2) = 8.905, P = 0.003) and a 
      significant decrease in the frequency of the GG genotype (OR = 0.516, chi(2) = 
      4.613, P = 0.032) in the NSCLC patients, compared to controls. The frequencies of 
      AA, AG and GG genotypes did not differ in the NSCLC patients according to the 
      number of pack-years smoked. Based on these results, we suggest that the MCP-1 
      -2518A/G polymorphism is associated with genetic susceptibility to NSCLC.
FAU - Yang, L
AU  - Yang L
AD  - Department of Thoracic Surgeon, Beijing Tuberculosis and Thoracic Tumor Research 
      Institute, Beijing, P.R. China.
FAU - Shi, G L
AU  - Shi GL
FAU - Song, C X
AU  - Song CX
FAU - Xu, S F
AU  - Xu SF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100427
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Carcinoma, Non-Small-Cell Lung/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - China
MH  - Ethnicity/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Smoking/genetics
EDAT- 2010/05/08 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - gmr740 [pii]
AID - 10.4238/vol9-2gmr740 [doi]
PST - epublish
SO  - Genet Mol Res. 2010 Apr 27;9(2):765-71. doi: 10.4238/vol9-2gmr740.