PMID- 20450721
OWN - NLM
STAT- MEDLINE
DCOM- 20100909
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 90
IP  - 10
DP  - 2010 Mar 16
TI  - [Association between serum uric acid level and peripheral vascular disease of 
      lower extremities in type 2 diabetes mellitus subjects].
PG  - 653-7
AB  - OBJECTIVE: To investigate the relationship between serum uric acid (UA) level and 
      lower extremity arterial disease (LEAD) in type 2 diabetes mellitus (T2DM) 
      subjects. METHODS: A total of 2174 T2DM individuals (1228 males, 946 females) 
      were investigated. The case history, physical examination and biochemical tests 
      were conducted. And LEAD was diagnosed by high-resolution ultrasound. RESULTS: In 
      women, the serum UA levels with LEAD was significantly higher than that without 
      LEAD [(304 +/- 76) micromol/L vs (287 +/- 71) micromol/L, P < 0.01], but not in 
      men [(332 +/- 76) micromol/L vs (328 +/- 77) micromol/L, P = 0.45]. The subjects 
      were divided into 4 groups (groups A, B, C, D) according to sex-specific 
      quartiles of serum UA levels (< 240 micromol/L, 240 - 284 micromol/L, 285 - 340 
      micromol/L and >or= 341 micromol/L in women and< 275 micromol/L, 275 - 322 
      micromol/L, 323 - 377 micromol/L and >or= 378 micromol/L in men). In women, the 
      prevalence of LEAD of 4 groups were 38.56%, 44.02%, 47.54% and 50.00% 
      respectively (P < 0.01). And the prevalence of LEAD in groups C and D was 
      significantly higher than that in group A (P < 0.05). But in men there was no 
      significant difference between 4 groups. After adjusting for age, duration of 
      diabetes mellitus, smoking status, systolic blood pressure, body mass index, 
      total cholesterol, triglyceride and C reactive protein, the serum UA levels in 
      women was an independent risk factor associated with the prevalence of LEAD. And 
      the odds ratios (95%CI) of sex-specific quartiles of serum UA were 1.0, 1.25 
      (0.87 to 1.81), 1.44 (1.01 to 2.08) and 1.59 (1.10 to 2.30) respectively. 
      CONCLUSION: The increase of serum UA levels is associated with LEAD in women, in 
      addition to age, duration of diabetes mellitus, smoking status, systolic blood 
      pressure, body mass index, total cholesterol, triglyceride and C reactive 
      protein. Serum UA levels is an independent risk factor of LEAD in women 
      diabetics.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Shanghai Clinical Center for Diabetes, Department of Endocrinology & Metabolism, 
      Sixth People's Hospital Affiliated to Jiaotong University, Shanghai Diabetes 
      Institute, Shanghai 200233, China.
FAU - Zhou, Jian
AU  - Zhou J
FAU - Li, Qing
AU  - Li Q
FAU - Yu, Hao-yong
AU  - Yu HY
FAU - Li, Ming
AU  - Li M
FAU - Zhang, Feng
AU  - Zhang F
FAU - Bao, Yu-qian
AU  - Bao YQ
FAU - Jia, Wei-ping
AU  - Jia WP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Lower Extremity/blood supply
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*etiology
MH  - Sex Factors
MH  - Uric Acid/*blood
EDAT- 2010/05/11 06:00
MHDA- 2010/09/10 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/09/10 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):653-7.