PMID- 20450744
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20161125
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Mar
TI  - [The levels of dioxin in 60 human breast milk samples and the exposure risk 
      factor analysis in Shenzhen].
PG  - 224-9
AB  - OBJECTIVE: To investigate the levels of polychlorinated dibenzo-p-dioxins and 
      polychlorinated dibenzo-p-furans (PCDD-Fs) in human breast milk of the mothers 
      who lived in non-directly persistent organic pollutants (POPs) polluted area in 
      Shenzhen, and the correlation of exposure risk factor was analyzed. METHODS: From 
      July to November in 2007, 60 primiparas by vaginal delivery after parturition 3 
      weeks to 2 months were sampled for breast milk who aged from 20 - 34 years old 
      and has lived in Shenzhen non-directly POPs polluted areas over 5 years. PCDD-Fs 
      were extracted from the frozen-dried samples with accelerated solvent extraction 
      (ASE), cleaned up by fluid management system (FMS) and quantified by 
      high-resolution gas chromatography-high resolution mass spectrometry (HRGC-HRMS) 
      using isotope dilution methodology. TEQ were calculated. The correlation 
      relationship among infant's birth weight and length, participatory's dietary, 
      age, inhabitation period, environment and the body burden of PCDD-Fs in mother 
      was statistically analyzed by SPSS 13.0. RESULTS: The participants aged from 20 - 
      34 years old (28 years on average) and lived in Shenzhen for 5 - 29 years (10 
      years on average). The concentration of PCDD-Fs in 60 breast milk samples were 
      26.957 143 - 669.583 333 pg/g fat (mean: 7.224 817 pg/g fat, median: 84.176 062 
      pg/g fat), and TEQ-PCDD-Fs in samples were 2.420 793 - 29.014 277 pg/g fat (mean: 
      8.645 992 pg/g fat, median: 7.751 804 pg/g fat). 2, 3, 4, 7, 8-PeCDF, 1, 2, 3, 7, 
      8-PeCDD, 2, 3, 7, 8-TCDD were the dominant contributors to the total TEQ, which 
      were 3.691 654 pg/g fat (42.689 378%), 2.478 315 pg/g fat (28.652 356%), and 
      0.980 995 pg/g fat (11.343 995%) respectively. Significant positive correlations 
      were found among age (r = 0.26, P < 0.05), inhabitation period (r = 0.49, P < 
      0.05), the consumption of fish (r = 0.37, P < 0.05) and the concentrations of 
      TEQ-PCDD-Fs in the study. CONCLUSION: The levels of dioxin chemicals in the 
      breast milk samples in non-directly POPs polluted areas of Shenzhen are high. 
      Significant positive correlations were found among age, inhabitation period, the 
      consumption of fish and the concentration of PCDD-Fs.
FAU - Deng, Bo
AU  - Deng B
AD  - POPs Lab, Shenzhen Center for Disease Prevention and Control, Shenzhen 518020, 
      China.
FAU - Zhang, Jian-qing
AU  - Zhang JQ
FAU - Zhang, Li-shi
AU  - Zhang LS
FAU - Jiang, You-sheng
AU  - Jiang YS
FAU - Zhou, Jian
AU  - Zhou J
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (Dioxins)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 290-67-5 (1,4-dioxin)
RN  - 2NE6H0QPCH (1,2,3,7,8-pentachlorodibenzo-p-dioxin)
RN  - O1B5KJ235I (dibenzo(1,4)dioxin)
SB  - IM
MH  - Adult
MH  - China
MH  - Dioxins/*analysis
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Milk, Human/*chemistry
MH  - Mothers
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/analysis
MH  - Risk Assessment
MH  - Young Adult
EDAT- 2010/05/11 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2010 Mar;44(3):224-9.