PMID- 2045089
OWN - NLM
STAT- MEDLINE
DCOM- 19910716
LR  - 20191022
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 25
IP  - 1
DP  - 1991 Mar
TI  - A contributory role for midbrain progesterone in the facilitation of female 
      sexual behavior in rats.
PG  - 19-28
AB  - Progesterone (P) facilitation of sexual receptivity in rodents has been achieved 
      by intracranial administration to the ventral hypothalamus; the preoptic area; 
      and midbrain areas such as central gray, mesencephalic reticular formation, and 
      ventral tegmental nucleus. In our laboratory, by far the most effective site in 
      rats has been the ventromedial nucleus of the hypothalamus (VMN). However, 
      several reports of sensitivity to P in the midbrain of rats and other rodent 
      species led us to investigate whether stimulation of the ventral midbrain of 
      female rats might contribute to facilitation of sexual receptivity. 
      Ovariectomized Long-Evans rats received one cannula aimed at the VMN, and another 
      aimed at the contralateral ventral mesencephalon. P in both cannulae, following a 
      priming dose of estradiol, caused significantly higher lordosis quotients (LQ) 
      than blank tubes. Controls with bilateral cannulae in the VMN responded when both 
      tubes were filled with P, but did not respond to unilateral VMN P stimulation. P 
      in the VMN and contralateral anterior preoptic area did not result in a greater 
      degree of receptivity than did the empty tubes. These studies indicate that 
      although progesterone stimulation in the midbrain alone is not sufficient to 
      facilitate receptivity in female rats with our methods, the midbrain may play an 
      auxiliary role. P implants in the midbrain appear to facilitate receptivity in 
      the case of VMN implant treatments that are subthreshold for stimulating 
      lordosis. The results are discussed in light of similar studies in other rodent 
      species, and in the context that more than one brain site may be important in the 
      natural stimulation of sexual receptivity by gonadal hormones.
FAU - Pleim, E T
AU  - Pleim ET
AD  - Department of Biological Sciences, Rutgers University, New Brunswick, New Jersey 
      08903.
FAU - Baumann, J
AU  - Baumann J
FAU - Barfield, R J
AU  - Barfield RJ
LA  - eng
GR  - HD-04484/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Mesencephalon/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Estrogen/physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1016/0018-506x(91)90036-h [doi]
PST - ppublish
SO  - Horm Behav. 1991 Mar;25(1):19-28. doi: 10.1016/0018-506x(91)90036-h.