PMID- 20450951
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220331
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 48
IP  - 8-9
DP  - 2010 Aug-Sep
TI  - Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and 
      fatty liver disease in rats fed high fat plus fructose diet.
PG  - 2021-9
LID - 10.1016/j.fct.2010.04.044 [doi]
AB  - The study evaluated the protective effects of Cissus quadrangularis stem extract 
      (CQEt) on oxidant-antioxidant balance and insulin resistance (IR) in rats fed 
      high fat-high fructose diet (HFFD) and also tested its free-radical scavenging 
      property in vitro. Rats were fed either control diet or HFFD for 15 days, 
      following which the diet was fortified with CQEt at a dose of 10 g/100g diet. 
      After 60 days, HFFD caused deleterious metabolic effects, including 
      hyperglycemia, IR and liver dysfunction. Rats fed HFFD alone showed increased 
      activities of hepatocellular enzymes in plasma, lipid deposition, significant 
      decline in antioxidants, and elevated lipid peroxidation indices and protein 
      carbonyl in liver. CQEt addition significantly improved insulin sensitivity, 
      reduced liver damage and oxidative changes, and brought back the antioxidants and 
      lipids towards normal. Histopathology of the liver confirmed the changes induced 
      by HFFD and the heptoprotective effect of CQEt. The effects of CQEtin vivo were 
      comparable with that of standard drug, metformin. Through in vitro assays, CQEt 
      was found to contain large quantities of polyphenols, vitamins C and E. CQEt 
      exhibited radical scavenging ability in a dose-dependent manner. These data 
      suggest that CQEt affords hepatoprotection by its antioxidant and 
      insulin-sensitizing activities.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Chidambaram, Jaya
AU  - Chidambaram J
AD  - Department of Biochemistry and Biotechnology, Annamalai University, Annamalai 
      Nagar 608 002, Tamil Nadu, India.
FAU - Carani Venkatraman, Anuradha
AU  - Carani Venkatraman A
LA  - eng
PT  - Journal Article
DEP - 20100505
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Dietary Fats)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Oxidants)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/pharmacology
MH  - Body Weight/drug effects
MH  - Cissus/*chemistry
MH  - Diet
MH  - Dietary Fats/*adverse effects
MH  - Fatty Liver/chemically induced/*drug therapy/enzymology
MH  - Free Radical Scavengers/metabolism
MH  - Fructose/*adverse effects
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin Resistance/*physiology
MH  - Lipid Metabolism/drug effects
MH  - Lipid Peroxidation/drug effects
MH  - Liver Function Tests
MH  - Male
MH  - Organ Size/drug effects
MH  - Oxidants/chemistry
MH  - Oxidative Stress/*drug effects
MH  - Phenols/analysis
MH  - Plant Extracts/chemistry/pharmacology
MH  - Plant Stems/chemistry
MH  - Rats
MH  - Rats, Wistar
EDAT- 2010/05/11 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/12/04 00:00 [received]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - S0278-6915(10)00258-9 [pii]
AID - 10.1016/j.fct.2010.04.044 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2021-9. doi: 10.1016/j.fct.2010.04.044. 
      Epub 2010 May 5.