PMID- 20451466
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20130520
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 11
IP  - 12
DP  - 2010 Dec
TI  - Sustained nociceptive mechanical stimulation of latent myofascial trigger point 
      induces central sensitization in healthy subjects.
PG  - 1348-55
LID - 10.1016/j.jpain.2010.03.010 [doi]
AB  - The aim of the study is to test if sustained nociceptive mechanical stimulation 
      (SNMS) of latent myofascial trigger points (MTrPs) induces widespread mechanical 
      hyperalgesia. SNMS was obtained by inserting and retaining an intramuscular 
      electromyographic (EMG) needle within a latent MTrP or a nonMTrP in the finger 
      extensor muscle for 8 minutes in 12 healthy subjects. Pain intensity (VAS) and 
      referred pain area induced by SNMS were recorded. Pressure pain threshold (PPT) 
      was measured immediately before and after, and 10-, 20-, and 30-minutes after 
      SNMS at the midpoint of the contralateral tibialis anterior muscle. Surface and 
      intramuscular EMG during SNMS were recorded. When compared to nonMTrPs, maximal 
      VAS and the area under VAS curve (VASauc) were significantly higher and larger 
      during SNMS of latent MTrPs (both, P < .05); there was a significant decrease in 
      PPT 10 minutes, 20 minutes, and 30 minutes postSNMS of latent MTrPs (all, P < 
      .05). Muscle cramps following SNMS of latent MTrPs were positively associated 
      with VASauc (r = .72, P = .009) and referred pain area (r = .60, P = .03). 
      Painful stimulation of latent MTrPs can initiate widespread central 
      sensitization. Muscle cramps contribute to the induction of local and referred 
      pain. PERSPECTIVE: This study shows that MTrPs are one of the important 
      peripheral pain generators and initiators for central sensitization. Therapeutic 
      methods for decreasing the sensitivity and motor-unit excitability of MTrPs may 
      prevent the development of muscle cramps and thus decrease local and referred 
      pain.
CI  - Copyright (c) 2010 American Pain Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Xu, Yi-Meng
AU  - Xu YM
AD  - Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor 
      Interaction (SMI), Department of Health Science and Technology, Aalborg 
      University, Aalborg, Denmark.
FAU - Ge, Hong-You
AU  - Ge HY
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100506
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
SB  - IM
MH  - Adult
MH  - Electromyography
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Cramp/*etiology
MH  - Muscle, Skeletal/physiology
MH  - Myofascial Pain Syndromes/*complications
MH  - Pain Measurement/methods
MH  - Pain Threshold
MH  - Pain, Referred/*etiology
EDAT- 2010/05/11 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/01/26 00:00 [received]
PHST- 2010/03/09 00:00 [revised]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S1526-5900(10)00425-6 [pii]
AID - 10.1016/j.jpain.2010.03.010 [doi]
PST - ppublish
SO  - J Pain. 2010 Dec;11(12):1348-55. doi: 10.1016/j.jpain.2010.03.010. Epub 2010 May 
      6.