PMID- 20451897
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20220330
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 150
IP  - 1
DP  - 2010 Jul
TI  - The association between percent disruption of the photoreceptor inner 
      segment-outer segment junction and visual acuity in diabetic macular edema.
PG  - 63-67.e1
LID - 10.1016/j.ajo.2010.01.039 [doi]
AB  - PURPOSE: To evaluate the integrity of the photoreceptor inner segment/outer 
      segment (IS/OS) junction using spectral-domain optical coherence tomography (SD 
      OCT) in patients with diabetic macular edema and to correlate the relationship 
      between the integrity of the IS/OS junction and visual acuity. DESIGN: 
      Retrospective, comparative, consecutive case series. METHODS: Sixty-two eyes from 
      38 patients with diabetic macular edema underwent SD OCT imaging. For each 
      patient, 2 experienced observers masked to visual acuity measured several SD OCT 
      variables, including central macular thickness, retinal volume, global disruption 
      scale of outer retina, percentage disruption of the outer retina, and history of 
      previous treatments. Visual acuity recorded as number of Early Treatment Diabetic 
      Retinopathy Study letters was used as the outcome variable in univariate and 
      multivariate analysis testing the measured SD OCT variables as predictors. 
      RESULTS: A statistically significant correlation between percentage disruption of 
      the IS/OS junction and visual acuity was found (P = .0312). Additionally, there 
      was a strong trend suggesting a relationship between macular volume and visual 
      acuity, although borderline significance was found (P = .07). CONCLUSIONS: 
      Disruption of the photoreceptor IS/OS junction is an important predictor of 
      visual acuity among diabetic macular edema patients.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Maheshwary, Anjali S
AU  - Maheshwary AS
AD  - Jacobs Retina Center, Department of Ophthalmology, University of California at 
      San Diego, La Jolla, USA.
FAU - Oster, Stephen F
AU  - Oster SF
FAU - Yuson, Ritchie M S
AU  - Yuson RM
FAU - Cheng, Lingyun
AU  - Cheng L
FAU - Mojana, Francesca
AU  - Mojana F
FAU - Freeman, William R
AU  - Freeman WR
LA  - eng
GR  - R01 EY007366/EY/NEI NIH HHS/United States
GR  - R01 EY007366-22/EY/NEI NIH HHS/United States
GR  - EY07366/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100510
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Diabetic Retinopathy/diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Macular Edema/diagnosis/*physiopathology
MH  - Male
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
PMC - PMC2900476
MID - NIHMS182512
EDAT- 2010/05/11 06:00
MHDA- 2010/07/28 06:00
PMCR- 2011/07/01
CRDT- 2010/05/11 06:00
PHST- 2009/10/26 00:00 [received]
PHST- 2010/01/28 00:00 [revised]
PHST- 2010/01/29 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0002-9394(10)00106-6 [pii]
AID - 10.1016/j.ajo.2010.01.039 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2010 Jul;150(1):63-67.e1. doi: 10.1016/j.ajo.2010.01.039. Epub 
      2010 May 10.