PMID- 20453853
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20220409
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 13
IP  - 6
DP  - 2010 Jun
TI  - Representation and transformation of sensory information in the mouse accessory 
      olfactory system.
PG  - 723-30
LID - 10.1038/nn.2546 [doi]
AB  - In mice, nonvolatile social cues are detected and analyzed by the accessory 
      olfactory system (AOS). Here we provide a first view of information processing in 
      the AOS with respect to individual chemical cues. 12 sulfated steroids, recently 
      discovered mouse AOS ligands, caused widespread activity among vomeronasal 
      sensory neurons (VSNs), yet VSN responses clustered into a small number of 
      repeated functional patterns or processing streams. Downstream neurons in the 
      accessory olfactory bulb (AOB) responded to these ligands with enhanced 
      signal/noise compared to VSNs. Although the dendritic connectivity of AOB mitral 
      cells suggests the capacity for broad integration, most sulfated steroid 
      responses were well-modeled by linear excitatory drive from just one VSN 
      processing stream. However, a substantial minority demonstrated multi-stream 
      integration. Most VSN excitation patterns were also observed in the AOB, but 
      excitation by estradiol sulfate processing streams was rare, suggesting AOB 
      circuit organization is specific to the biological relevance of sensed cues.
FAU - Meeks, Julian P
AU  - Meeks JP
AD  - Department of Anatomy and Neurobiology, Washington University School of Medicine, 
      St. Louis, Missouri, USA.
FAU - Arnson, Hannah A
AU  - Arnson HA
FAU - Holy, Timothy E
AU  - Holy TE
LA  - eng
GR  - R01 DC010381/DC/NIDCD NIH HHS/United States
GR  - F32DC009352/DC/NIDCD NIH HHS/United States
GR  - R01DC010381/DC/NIDCD NIH HHS/United States
GR  - F32 DC009352/DC/NIDCD NIH HHS/United States
GR  - R01 DC010381-01/DC/NIDCD NIH HHS/United States
GR  - R01 DC005964/DC/NIDCD NIH HHS/United States
GR  - R01 DC005964-06A2/DC/NIDCD NIH HHS/United States
GR  - F32 DC009352-02/DC/NIDCD NIH HHS/United States
GR  - R01DC005964/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100509
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Steroids)
RN  - 0 (Sulfates)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Cluster Analysis
MH  - Cues
MH  - Dendrites/physiology
MH  - Estradiol
MH  - In Vitro Techniques
MH  - Linear Models
MH  - Male
MH  - Mice
MH  - Microelectrodes
MH  - Models, Neurological
MH  - Olfactory Bulb/*physiology
MH  - Olfactory Perception/*physiology
MH  - Physical Stimulation
MH  - Sensory Receptor Cells/*physiology
MH  - Social Perception
MH  - Steroids
MH  - Sulfates
MH  - Urine
MH  - Vomeronasal Organ/*physiology
PMC - PMC2930753
MID - NIHMS195190
EDAT- 2010/05/11 06:00
MHDA- 2010/06/15 06:00
PMCR- 2010/12/01
CRDT- 2010/05/11 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/04/08 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - nn.2546 [pii]
AID - 10.1038/nn.2546 [doi]
PST - ppublish
SO  - Nat Neurosci. 2010 Jun;13(6):723-30. doi: 10.1038/nn.2546. Epub 2010 May 9.