PMID- 20455559
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100616
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 58
IP  - 12
DP  - 2010 Jun 23
TI  - Dietary carotenoids inhibit oral sensitization and the development of food 
      allergy.
PG  - 7180-6
LID - 10.1021/jf100519x [doi]
AB  - Type-I allergic disorders and particularly food hypersensitivities are becoming 
      increasingly common worldwide. This study investigated whether dietary enrichment 
      with carotenoids inhibited oral sensitization to an antigen and the development 
      of food allergies. The effects of a diet high in carotenoids were investigated in 
      B10A mice that were orally sensitized to ovalbumin (OVA). The serum titers of 
      OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a were inhibited in mice fed 
      ad libitum on a diet high in alpha- or beta-carotene compared to the control mice 
      when orally sensitized to OVA. High alpha- and beta-carotene diets inhibited the 
      immediate reduction in body temperature and rise in serum histamine associated 
      with active systemic anaphylaxis in OVA-sensitized B10A mice. After 
      re-stimulation with OVA in vitro, the production of T-helper 2-type cytokines by 
      splenocytes from mice fed a diet high in carotenoids was lower than in control 
      mice. Furthermore, the proportion of CD4(+) CD103(+) T cells in Peyer's patches 
      of mice fed a carotenoid-rich diet was significantly lower than in control mice. 
      These results suggest that an increased oral intake of carotenoids inhibits 
      OVA-specific IgE and IgG1 production and antigen-induced anaphylactic responses 
      by inhibiting specific T-cell activation in the mucosal immune system. A diet 
      high in carotenoids might therefore prevent the development of food allergies.
FAU - Sato, Yuji
AU  - Sato Y
AD  - National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
FAU - Akiyama, Hiroshi
AU  - Akiyama H
FAU - Matsuoka, Hideki
AU  - Matsuoka H
FAU - Sakata, Kozue
AU  - Sakata K
FAU - Nakamura, Rika
AU  - Nakamura R
FAU - Ishikawa, Shingo
AU  - Ishikawa S
FAU - Inakuma, Takahiro
AU  - Inakuma T
FAU - Totsuka, Mamoru
AU  - Totsuka M
FAU - Sugita-Konishi, Yoshiko
AU  - Sugita-Konishi Y
FAU - Ebisawa, Motohiro
AU  - Ebisawa M
FAU - Teshima, Reiko
AU  - Teshima R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 36-88-4 (Carotenoids)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Carotenoids/*administration & dosage
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Food Hypersensitivity/*diet therapy/immunology/*prevention & control
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Immunoglobulin G/blood/immunology
MH  - Mice
MH  - Ovalbumin/administration & dosage/immunology
MH  - T-Lymphocytes/immunology
EDAT- 2010/05/12 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 10.1021/jf100519x [doi]
PST - ppublish
SO  - J Agric Food Chem. 2010 Jun 23;58(12):7180-6. doi: 10.1021/jf100519x.