PMID- 20456252
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20131121
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 90
IP  - 2
DP  - 2012 Mar
TI  - Chemokines in aqueous humour before and after intravitreal triamcinolone 
      acetonide in eyes with macular oedema associated with branch retinal vein 
      occlusion.
PG  - 162-7
LID - 10.1111/j.1755-3768.2010.01892.x [doi]
AB  - PURPOSE: To determine the aqueous humour levels of chemokines before and after an 
      intravitreal injection of triamcinolone acetonide (IVTA) in eyes with macular 
      oedema associated with a branch retinal vein occlusion (ME-BRVO). DESIGN:   
      Single-centre, prospective, consecutive interventional case series. PARTICIPANTS: 
      Seventeen eyes of 17 consecutive patients with ME-BRVO who underwent IVTA were 
      studied. Seven eyes without retinal vascular disease served as control. 
      INTERVENTION: All patients with ME-BRVO underwent IVTA. MAIN OUTCOME MEASURES: 
      The optical coherence tomographically determined foveal thickness (FT) and the 
      aqueous humour levels of inflammatory chemokines of the C-C subfamily, including 
      eotaxin, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory 
      protein-1alpha (MIP-1alpha), beta (MIP-1beta), and RANTES was determined before the IVTA 
      (baseline) and at 1 week after the IVTA. RESULTS: At the baseline, only MCP-1 and 
      MIP-1beta were detected in the aqueous, and MIP-1beta was significantly higher in eyes 
      with a ME-BRVO than in controls (p = 0.004). The level of both of these 
      chemokines was not correlated with the FT (p = 0.654 and p = 0.608, 
      respectively). One week after IVTA, the FT was significantly decreased (p < 
      0.001), and the levels of MCP-1 and MIP-1beta were also significantly reduced (p < 
      0.001 and p = 0.044, respectively). The decrease in the FT was correlated with 
      the decrease in only MIP-1beta (r = 0.58, p = 0.020). CONCLUSIONS: Alterations of 
      the aqueous level of MIP-1beta reflect the improvement of the macular oedema after 
      IVTA in eyes with ME-BRVO. This indicates that the steroid-dependent ME-BRVO was 
      closely related with the level of MIP-1beta.
CI  - (c) 2010 The Authors. Acta Ophthalmologica (c) 2010 Acta Ophthalmologica Scandinavica 
      Foundation.
FAU - Kunikata, Hiroshi
AU  - Kunikata H
AD  - Department of Ophthalmology and Visual Science, Tohoku University Graduate School 
      of Medicine, Sendai 980-8574, Japan. kunikata@oph.med.tohoku.ac.jp
FAU - Shimura, Masahiko
AU  - Shimura M
FAU - Nakazawa, Toru
AU  - Nakazawa T
FAU - Sonoda, Koh-Hei
AU  - Sonoda KH
FAU - Yoshimura, Takeru
AU  - Yoshimura T
FAU - Ishibashi, Tatsuro
AU  - Ishibashi T
FAU - Nishida, Kohji
AU  - Nishida K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100423
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL4 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokines)
RN  - 0 (Glucocorticoids)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aqueous Humor/*metabolism
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CCL4/metabolism
MH  - Chemokines/*metabolism
MH  - Female
MH  - Fovea Centralis/pathology
MH  - Glucocorticoids/*administration & dosage
MH  - Humans
MH  - Intravitreal Injections
MH  - Macular Edema/*drug therapy/metabolism
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Vein Occlusion/*drug therapy/metabolism
MH  - Tomography, Optical Coherence
MH  - Triamcinolone Acetonide/*administration & dosage
EDAT- 2010/05/12 06:00
MHDA- 2013/01/31 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - AOS1892 [pii]
AID - 10.1111/j.1755-3768.2010.01892.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2012 Mar;90(2):162-7. doi: 10.1111/j.1755-3768.2010.01892.x. 
      Epub 2010 Apr 23.