PMID- 2045632 OWN - NLM STAT- MEDLINE DCOM- 19910716 LR - 20170214 IS - 0883-0738 (Print) IS - 0883-0738 (Linking) VI - 6 IP - 2 DP - 1991 Apr TI - HLA patterns in children with parainflammatory leukoencephalomyelitis. PG - 150-4 AB - We have evaluated the human leukocyte antigen (HLA) phenotype of six children with parainflammatory leukoencephalomyelitis (PIL). Patients with PIL demonstrate an increased prevalence of the HLA-A1, -A28, -B44, -DR6, and -DR7 antigens. These HLA associations are different from those reported in other inflammatory demyelinating diseases, including multiple sclerosis, optic neuritis, Guillain-Barre syndrome, and chronic relapsing inflammatory polyneuropathy. The HLA constitution of the patient appears to be one important host factor in determining the nature of the immune response to an encephalitogenic challenge. FAU - Marks, W A AU - Marks WA AD - Fort Worth Child Neurology Associates, Fort Worth, TX 76104. FAU - Shuman, R M AU - Shuman RM FAU - Bodensteiner, J B AU - Bodensteiner JB LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 RN - 0 (HLA Antigens) SB - IM MH - Child MH - Child, Preschool MH - Diagnosis, Differential MH - Encephalomyelitis/*diagnosis MH - Female MH - HLA Antigens/*analysis MH - Humans MH - Male MH - Multiple Sclerosis/diagnosis MH - Phenotype EDAT- 1991/04/01 00:00 MHDA- 1991/04/01 00:01 CRDT- 1991/04/01 00:00 PHST- 1991/04/01 00:00 [pubmed] PHST- 1991/04/01 00:01 [medline] PHST- 1991/04/01 00:00 [entrez] AID - 10.1177/088307389100600211 [doi] PST - ppublish SO - J Child Neurol. 1991 Apr;6(2):150-4. doi: 10.1177/088307389100600211.