PMID- 20456412
OWN - NLM
STAT- MEDLINE
DCOM- 20100827
LR  - 20231213
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 161
IP  - 2
DP  - 2010 Aug
TI  - Immune modulation of co-transplantation mesenchymal stem cells with islet on T 
      and dendritic cells.
PG  - 357-63
LID - 10.1111/j.1365-2249.2010.04178.x [doi]
AB  - Allogeneic pancreatic islet transplantation theoretically represents a cure for 
      type 1 diabetes. However, current immune suppressive therapies are often 
      associated with undesired side effects. Given this problem, and the shortage of 
      human islet donors, the majority of type 1 diabetes patients cannot currently be 
      offered an islet transplant. However, it has been found that mesenchymal stem 
      cells (MSCs) could exert unique immunosuppressive effects both in vitro and in 
      vivo. Herein we transplanted allogeneic 200 islets alone or in combination with 
      MSCs (3 x 10(6) cells) under the kidney capsules of diabetic C57LB/6 mouse. We 
      found that the ratios of T helper type 1 (Th1) to Th2 and Tc1 to Tc2 were 
      reduced, and the numbers of naive and memory T cells were down-regulated in 
      peripheral blood after transplantation. In addition, the maturation, endocytosis 
      and interleukin-12 secretion of dendritic cell (DCs)-derived bone marrow cells 
      (BMCs) from receptor mice were suppressed. Rejection reaction was alleviated by 
      MSCs which exerted suppressive effects through T lymphocyte subsets and DCs.
FAU - Li, F R
AU  - Li FR
AD  - Clinical Medical Research Center, the Second Clinical Medical College (Shenzhen 
      People's Hospital) Ji'nan University, Shenzhen, China. frli62@yahoo.com
FAU - Wang, X G
AU  - Wang XG
FAU - Deng, C Y
AU  - Deng CY
FAU - Qi, H
AU  - Qi H
FAU - Ren, L L
AU  - Ren LL
FAU - Zhou, H X
AU  - Zhou HX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100507
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Blood Glucose)
RN  - 0 (CD11c Antigen)
RN  - 0 (Dextrans)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 187348-17-0 (Interleukin-12)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology/therapeutic use
MH  - Antigens, CD/metabolism
MH  - B7-2 Antigen/metabolism
MH  - Blood Glucose/metabolism
MH  - Bone Marrow Cells/cytology
MH  - CD11c Antigen/metabolism
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Dextrans/immunology
MH  - Diabetes Mellitus, Experimental/blood/pathology/*therapy
MH  - Immunoglobulins/metabolism
MH  - Immunomodulation/*immunology
MH  - Interleukin-12/metabolism
MH  - Islets of Langerhans Transplantation/*methods
MH  - Kidney/pathology
MH  - Leukocyte Common Antigens/immunology
MH  - Lymphocyte Count
MH  - Male
MH  - Membrane Glycoproteins/metabolism
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Phagocytosis/immunology
MH  - T-Lymphocytes/cytology/*immunology
MH  - T-Lymphocytes, Cytotoxic/cytology/immunology
MH  - Th1 Cells/cytology/immunology
MH  - Th2 Cells/cytology/immunology
MH  - CD83 Antigen
PMC - PMC2909419
EDAT- 2010/05/12 06:00
MHDA- 2010/08/28 06:00
PMCR- 2011/08/01
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/08/28 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - CEI4178 [pii]
AID - 10.1111/j.1365-2249.2010.04178.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2010 Aug;161(2):357-63. doi: 10.1111/j.1365-2249.2010.04178.x. 
      Epub 2010 May 7.