PMID- 20456519
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20221207
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 32
IP  - 6 Pt 2
DP  - 2010 Dec
TI  - An allelic typing method for 2DS4 variant used in study of haplotypes of killer 
      cell immunoglobulin-like receptor gene.
PG  - 625-32
LID - 10.1111/j.1751-553X.2010.01234.x [doi]
AB  - The KIR2DS4 variants differ in exon 5 and play a role in hematopoietic stem cells 
      transplantation (HSCT). A sequence-based testing (SBT) and TOPO TA cloning system 
      identifying and distinguishing alleles of the KIR2DS4 gene was established and 
      applied to a total of 150 Chinese-Han individuals: 75 patients received 
      T-cell-depleted HSCT and their unrelated donors. The majority (139) of the 150 
      samples (92.7%) were positive for KIR2DS4. Four of the nine known KIR2DS4 
      alleles, KIR2DS4 *00101, *003,*004, and *007, were identified. In the haplotype 
      A/A group, a higher risk of acute graft-versus-host disease (aGVHD) was seen when 
      the donor carried two full-length KIR2DS4 alleles (RR 9.0 [95% CI 1.2-66.9], P = 
      0.010). Our findings suggested that the expression of full-length 2DS4 (*001) in 
      A/A group may contribute to a worse clinical outcome after URD-HSCT. These data 
      would be beneficial for the selection of suitable donors.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Bao, X
AU  - Bao X
AD  - Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Jiangsu 
      Institute of Hematology, the First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, China.
FAU - Hou, L
AU  - Hou L
FAU - Sun, A
AU  - Sun A
FAU - Chen, M
AU  - Chen M
FAU - Chen, Z
AU  - Chen Z
FAU - He, J
AU  - He J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
RN  - 0 (KIR2DS4 protein, human)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/genetics
MH  - Haplotypes
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/*genetics
MH  - Tissue Donors
EDAT- 2010/05/12 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - CLH1234 [pii]
AID - 10.1111/j.1751-553X.2010.01234.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2010 Dec;32(6 Pt 2):625-32. doi: 
      10.1111/j.1751-553X.2010.01234.x.