PMID- 20457247
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 28
IP  - 6
DP  - 2010 Oct
TI  - Development of fetal cerebral cortex: assessment of the folding conditions with 
      post-mortem magnetic resonance imaging.
PG  - 537-43
LID - 10.1016/j.ijdevneu.2010.05.001 [doi]
AB  - Quantitative data of fetal cortical folding and its developmental changes supply 
      important information in the estimation of fetal age and assessment of brain 
      maturation, so the increasing tendencies of cortical growth and its folding 
      conditions at the beginning of the second and third trimesters with post-mortem 
      Magnetic Resonance Imaging (MRI) were analyzed. 131 fetal specimens of 14-40 
      weeks gestational age (GA) were selected and scanned with 3.0 T MR. Then the 
      length of folded cortical margin (LFCM) and length of unfolded cortical margin 
      (LUCM) were measured by Photoshop and ZoomMagic software. Degrees of cortical 
      folding (DCF) were calculated by means of (LFCM-LUCM)/LFCM. Growth curves were 
      obtained between the 3 above values and GA, and significant differences in age 
      stages, hemispheres and genders were analyzed. The relationship between LFCM in 
      centimeters, DCF and GA in weeks was described by two exponential growth curves 
      [LFCM=5.325 exp(0.079GA); DCF=11.890 exp(0.043GA)]. The curves increased rapidly 
      after 26 weeks GA, which could be recognized as a cut-off point of fetal cortical 
      and sulcal development. LUCM and GA were described by a logarithmic growth curve 
      which slowed down after 26 weeks GA [LUCM=30.580 Ln(GA)-72.490]. Significant 
      differences of the 3 values before and after 26 weeks GA (p<0.01), but not any in 
      hemispheres and genders were noticed. These results, which may be valuable in 
      assessing normal brain development and can serve as a model in clinical settings, 
      indicate that the cerebral volume first increases and is then followed by 
      increases of the surface area.
CI  - Copyright 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Zhang, Zhonghe
AU  - Zhang Z
AD  - Research Center for Sectional and Imaging Anatomy, Shandong University School of 
      Medicine, Jinan, Shandong, China.
FAU - Liu, Shuwei
AU  - Liu S
FAU - Lin, Xiangtao
AU  - Lin X
FAU - Sun, Bo
AU  - Sun B
FAU - Yu, Taifei
AU  - Yu T
FAU - Geng, Hequn
AU  - Geng H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100510
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
SB  - IM
MH  - Aging/*pathology
MH  - Cerebral Cortex/*anatomy & histology/*embryology
MH  - Female
MH  - Fetus/*anatomy & histology/*embryology
MH  - Gestational Age
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
EDAT- 2010/05/12 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/05/12 06:00
PHST- 2009/12/10 00:00 [received]
PHST- 2010/03/14 00:00 [revised]
PHST- 2010/05/03 00:00 [accepted]
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - S0736-5748(10)00078-X [pii]
AID - 10.1016/j.ijdevneu.2010.05.001 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2010 Oct;28(6):537-43. doi: 10.1016/j.ijdevneu.2010.05.001. 
      Epub 2010 May 10.