PMID- 20459605
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20211020
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 10
DP  - 2010 May 6
TI  - Prognostic utility of chromosomal instability detected by fluorescence in situ 
      hybridization in fine-needle aspirates from oral squamous cell carcinomas.
PG  - 182
LID - 10.1186/1471-2407-10-182 [doi]
AB  - BACKGROUND: Although chromosomal instability (CIN) has been detected in many 
      kinds of human malignancies by means of various methods, there is no practical 
      assessment for small clinical specimens. In this study, we evaluated CIN in 
      fine-needle aspiration (FNA) biopsied oral squamous cell carcinomas (SCCs) using 
      fluorescence in situ hybridization (FISH) analysis, and investigated its 
      prognostic significance. METHODS: To evaluate CIN status of tumors, FISH with 
      genomic probes for the centromeres of chromosomes 7, 9, and 11 was performed on 
      specimens obtained by FNA from 77 patients with primary oral SCCs. RESULTS: 
      High-grade CIN (CIN3) was observed in 11.7% (9/77) of patients with oral SCCs and 
      was associated significantly with reduced disease-free survival (p = .008) and 
      overall survival (p = .003). Multivariate Cox proportional hazards analysis 
      showed that CIN status was significantly correlated with disease-free survival (p 
      = .035) and overall survival (p = .041). CONCLUSION: Analysis of CIN status using 
      FISH on FNA biopsy specimens may be useful in predicting of recurrence and poor 
      prognosis in patients with oral SCCs.
FAU - Sato, Hiroaki
AU  - Sato H
AD  - Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of 
      Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental 
      University, Tokyo, Japan.
FAU - Uzawa, Narikazu
AU  - Uzawa N
FAU - Takahashi, Ken-Ichiro
AU  - Takahashi K
FAU - Myo, Kunihiro
AU  - Myo K
FAU - Ohyama, Yoshio
AU  - Ohyama Y
FAU - Amagasa, Teruo
AU  - Amagasa T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100506
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biopsy, Fine-Needle
MH  - Carcinoma, Squamous Cell/*genetics/mortality/secondary/therapy
MH  - *Chromosomal Instability
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 9
MH  - Disease-Free Survival
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/mortality/pathology/therapy
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC2881888
EDAT- 2010/05/13 06:00
MHDA- 2010/08/17 06:00
PMCR- 2010/05/06
CRDT- 2010/05/13 06:00
PHST- 2009/08/19 00:00 [received]
PHST- 2010/05/06 00:00 [accepted]
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
PHST- 2010/05/06 00:00 [pmc-release]
AID - 1471-2407-10-182 [pii]
AID - 10.1186/1471-2407-10-182 [doi]
PST - epublish
SO  - BMC Cancer. 2010 May 6;10:182. doi: 10.1186/1471-2407-10-182.