PMID- 20460355
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20161125
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Aug
TI  - Intensive menstrual bleeding successfully treated with recombinant factor VIIa in 
      Glanzmann thrombasthenia.
PG  - 320-2
LID - 10.1177/1076029610364518 [doi]
AB  - Glanzmann thrombasthenia (GT) is a rare inherited qualitative platelet disorder 
      due to the deficiency or defect of platelet membrane glycoprotein (GP) IIb/IIIa 
      complex. Symptoms include purpura, petechiae, bruising, gingival bleeding, 
      epistaxis, and menorrhagia. Platelet transfusion is considered the standard 
      therapy for securing hemostasis in patients with GT when local measures and 
      antifibrinolytic agents are inadequate. However, repeated platelet transfusions 
      may result in GP IIb/IIIa and/or human leukocyte antigen (HLA) immunization and 
      development of platelet refractoriness. Recombinant factor VIIa (rFVIIa) has been 
      introduced as therapeutic alternative and has been suggested to be effective. 
      Recombinant factor VIIa is indicated in Europe for the treatment of GT refractory 
      of platelet transfusion. In previous studies, rFVIIa has been used in the 
      prophylactic treatment of bleeding in patients with GT undergoing pelvic surgery, 
      cesarean section, and vaginal delivery. In this article, we present a case of 
      intensive menstrual bleeding refractory to previous antifibrinolytic agents and 
      platelet transfusions but which responded well to treatment with rFVIIa. To our 
      knowledge, there is no study or reported case in the literature reporting 
      successful use of rFVIIa in a patient with excessive menstrual bleeding due to 
      GT.
FAU - Balci, Yasemin Isik
AU  - Balci YI
AD  - Denizli State Hospital, Denizli, Turkey. dryibalci@gmail.com
FAU - Karabulut, Aysun
AU  - Karabulut A
FAU - Kabukcu, Sibel
AU  - Kabukcu S
FAU - Sari, Ismail
AU  - Sari I
FAU - Keskin, Ali
AU  - Keskin A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100511
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Recombinant Proteins)
RN  - AC71R787OV (recombinant FVIIa)
RN  - EC 3.4.21.21 (Factor VIIa)
SB  - IM
MH  - Factor VIIa/*therapeutic use
MH  - Female
MH  - Humans
MH  - Menorrhagia/*drug therapy/etiology
MH  - Menstruation/drug effects
MH  - Recombinant Proteins/therapeutic use
MH  - Thrombasthenia/blood/complications/*drug therapy
MH  - Young Adult
EDAT- 2010/05/13 06:00
MHDA- 2012/03/29 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 1076029610364518 [pii]
AID - 10.1177/1076029610364518 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2011 Aug;17(4):320-2. doi: 10.1177/1076029610364518. 
      Epub 2010 May 11.